Valentina Lolli1, Francesco Molinari2, Jean-Pierre Pruvo3, Gustavo Soto Ares3. 1. Radiology department, Erasmus university hospital, 808, route de Lennik, 1070 Brussels, Belgium. Electronic address: valentina.lolli@erasme.ulb.ac.be. 2. Radiology department, Gustave-Dron hospital, 59200 Tourcoing, France. 3. Neuroradiology department, Roger-Salengro hospital, 59037 Lille, France.
Abstract
BACKGROUND AND PURPOSE: Cerebral sinovenous thrombosis (CSVT) represents an increasingly recognized cause of pediatric stroke. Our purpose was to assess gender and age differences in the etiology, clinical presentation, and imaging features of CSVT in neonates and older children. METHODS: Subjects aged newborn to 18 years diagnosed with CSVT at the Lille university hospital between 2011 and 2014 were included. RESULTS: Eleven neonates and 16 non-neonates constituted the study population. The incidence of CSVT was significantly higher in male newborns. Clinical presentation did not vary significantly between the groups. Risk factors were age-dependent, with acute systemic illnesses significantly predominating in neonates (54%), whereas local infections, prothrombotic conditions, and trauma were more common in older children (36, 27, and 27% respectively). No predisposing factor could be identified in 36% of the neonates as compared to less than 5% of the non-neonates. Thrombosis of the deep venous structures was documented in 73% of the neonates whereas involvement of the superficial sinuses was significantly more frequent in the non-neonates group. Venous infarctions and extraparenchymal hemorrhages were significantly more frequent in the neonates group. CONCLUSION: Male patients are at higher risk for CSVT than females. In neonates, involvement of the deep venous structures is significantly more common. Brain parenchymal and extraparenchymal changes occur more frequently in this age group than in older children.
BACKGROUND AND PURPOSE:Cerebral sinovenous thrombosis (CSVT) represents an increasingly recognized cause of pediatric stroke. Our purpose was to assess gender and age differences in the etiology, clinical presentation, and imaging features of CSVT in neonates and older children. METHODS: Subjects aged newborn to 18 years diagnosed with CSVT at the Lille university hospital between 2011 and 2014 were included. RESULTS: Eleven neonates and 16 non-neonates constituted the study population. The incidence of CSVT was significantly higher in male newborns. Clinical presentation did not vary significantly between the groups. Risk factors were age-dependent, with acute systemic illnesses significantly predominating in neonates (54%), whereas local infections, prothrombotic conditions, and trauma were more common in older children (36, 27, and 27% respectively). No predisposing factor could be identified in 36% of the neonates as compared to less than 5% of the non-neonates. Thrombosis of the deep venous structures was documented in 73% of the neonates whereas involvement of the superficial sinuses was significantly more frequent in the non-neonates group. Venous infarctions and extraparenchymal hemorrhages were significantly more frequent in the neonates group. CONCLUSION: Male patients are at higher risk for CSVT than females. In neonates, involvement of the deep venous structures is significantly more common. Brain parenchymal and extraparenchymal changes occur more frequently in this age group than in older children.
Authors: Aleksandra Mineyko; Adam Kirton; Lori Billinghurst; Nana Nino Tatishvili; Max Wintermark; Gabrielle deVeber; Christine Fox Journal: Pediatr Neurol Date: 2019-10-18 Impact factor: 3.372
Authors: Ryan J Felling; Sahar M A Hassanein; Jennifer Armstrong; Luis Aversa; Lori Billinghurst; Neil A Goldenberg; Jo Ellen Lee; Emily C Maxwell; Michael J Noetzel; Warren Lo Journal: Neurol Clin Pract Date: 2020-06