| Literature DB >> 26970624 |
Daria Onichtchouk1, Wolfgang Driever2.
Abstract
The transcription factors Pou5f1, Sox2, and Nanog are central regulators of pluripotency in mammalian ES and iPS cells. In vertebrate embryos, Pou5f1/3, SoxB1, and Nanog control zygotic genome activation and participate in lineage decisions. We review the current knowledge of the roles of these genes in developing vertebrate embryos from fish to mammals and suggest a model for pluripotency gene regulatory network functions in early development.Entities:
Keywords: Blastula; Differentiation; Embryo; Embryonic stem cells; Gene regulatory network; Oct4; Pattern formation; Pluripotency; Pou5f3; Zygotic genome activation
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Year: 2016 PMID: 26970624 DOI: 10.1016/bs.ctdb.2015.12.004
Source DB: PubMed Journal: Curr Top Dev Biol ISSN: 0070-2153 Impact factor: 4.897