Literature DB >> 26970203

Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells.

Takashi Sekiya1, Hiroko Nakatsukasa2, Qianjin Lu3, Akihiko Yoshimura4.   

Abstract

Regulatory T (Treg) cells are an essential cell subset for the maintenance of immune homeostasis. Treg cells are characterized by a distinct pattern of gene expression, including the upregulation of immune-suppressive genes and the silencing of inflammatory genes. The molecular mechanisms involved in the development and maintenance of Tregs have been extensively investigated. We have identified essential transcription factors NR4a and Smad2/3 in the development of thymic Tregs and induced Tregs, respectively. This article reviews the roles of transcription factors in the differentiation, maintenance, and function of Treg cells.
Copyright © 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Clostridium species; DNA methylation; Foxp3; Regulatory T cell; TGF-β; Transcription factors

Mesh：

Substances：

Year:  2016        PMID： 26970203     DOI： 10.1016/j.micinf.2016.02.004

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


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