Midori N Courtice1,2, Xiaorong Wang3, Sihao Lin1, Ignatius Tak Sun Yu3, D Wayne Berman4, Eiji Yano5. 1. Division of Occupational and Environmental Health, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China. 2. IOM Singapore. 3. Hong Kong Occupational and Environmental Health Academy, Hong Kong, China. 4. Aeolus, Inc., Albany, California. 5. Division of Public Health, Teikyo University Graduate School of Public Health, Tokyo, Japan.
Abstract
BACKGROUND: Cumulative fiber exposures, predominantly chrysotile, were estimated in a Chinese asbestos worker cohort and exposure-response relationships with lung cancer mortality and cumulative incidence of asbestosis were determined. METHODS: Individual time-dependent cumulative exposures were estimated for 577 asbestos workers, followed prospectively for 37 years. Occupational history and smoking data were obtained from company records and personal interviews; vital status and causes of death were ascertained from death registries and hospital records. Hazard ratios were generated for disease outcomes, with adjustments for smoking and age. RESULTS: Median cumulative fiber exposure for the cohort was 132.6 fiber-years/ml (IQR 89.3-548.4). Exposure-response relationships were demonstrated for both disease outcomes, with nearly sixfold and threefold increased risks seen at the highest exposure level for lung cancer deaths and asbestosis, respectively. CONCLUSION: Evidence using quantitative exposure estimates was provided for increased risks of lung cancer mortality and development of asbestosis in a predominantly chrysotile-exposed cohort.
BACKGROUND: Cumulative fiber exposures, predominantly chrysotile, were estimated in a Chinese asbestos worker cohort and exposure-response relationships with lung cancer mortality and cumulative incidence of asbestosis were determined. METHODS: Individual time-dependent cumulative exposures were estimated for 577 asbestos workers, followed prospectively for 37 years. Occupational history and smoking data were obtained from company records and personal interviews; vital status and causes of death were ascertained from death registries and hospital records. Hazard ratios were generated for disease outcomes, with adjustments for smoking and age. RESULTS: Median cumulative fiber exposure for the cohort was 132.6 fiber-years/ml (IQR 89.3-548.4). Exposure-response relationships were demonstrated for both disease outcomes, with nearly sixfold and threefold increased risks seen at the highest exposure level for lung cancer deaths and asbestosis, respectively. CONCLUSION: Evidence using quantitative exposure estimates was provided for increased risks of lung cancer mortality and development of asbestosis in a predominantly chrysotile-exposed cohort.
Authors: Yali Zeng; Yan Cui; Ji Ma; Tingting Huo; Faqin Dong; Qingbi Zhang; Jianjun Deng; Xu Zhang; Jie Yang; Yulin Wang Journal: Environ Sci Pollut Res Int Date: 2017-09-29 Impact factor: 4.223
Authors: Dongmug Kang; Yu-Young Kim; Minseung Shin; Min-Su Lee; Hee-Joo Bae; Se-Yeong Kim; Young-Ki Kim Journal: Int J Environ Res Public Health Date: 2018-08-02 Impact factor: 3.390