Arnaud Sauer1,2, Tristan Bourcier3, David Gaucher3, Ermanno Candolfi4, Claude Speeg-Schatz3. 1. Ophthalmology and Federation de Medecine Translationnelle de Strasbourg (FMTS), Strasbourg University Hospital, BP 426 - Nouvel Hôpital Civil, Strasbourg, France. arnaud.sauer@chru-strasbourg.fr. 2. Department of Parasitology, Strasbourg University Hospital, 3 Rue Koeberlé, 67000, Strasbourg, France. arnaud.sauer@chru-strasbourg.fr. 3. Ophthalmology and Federation de Medecine Translationnelle de Strasbourg (FMTS), Strasbourg University Hospital, BP 426 - Nouvel Hôpital Civil, Strasbourg, France. 4. Department of Parasitology, Strasbourg University Hospital, 3 Rue Koeberlé, 67000, Strasbourg, France.
Abstract
BACKGROUND: Congenital cataract is of particular interest because of the variability of etiologies and the inflammatory reaction that are often observed. The aim of the study was to describe intraocular levels of various inflammation-related cytokines of patients with congenital cataract and to study their correlations with clinical determinants. METHODS: We followed a cohort of 18 patients (18 eyes) with congenital cataract from a University hospital and measured levels of various inflammation-related cytokines in the aqueous humor of patients with congenital cataract, and compared these levels to those observed in a control group (patients with senile cataract) using multiplex immunoassay. Correlation analysis was used to study the possible correlation between intraocular levels of cytokines and clinical determinants. RESULTS: Compared with the control group, the group with congenital cataract showed clear and significantly elevated concentrations of inflammatory markers (IL-1β, IL-15, IFN-γ, IL-12, IL-6, IL-5, IL-9, MIP-1α, MCP-1 and IP-10). Postoperative intraocular inflammation and opacification of the posterior capsule seemed to be correlated with preoperative IL-1β, TNF-α and IL-6 levels. CONCLUSIONS: An inflammatory condition may occur in eyes with congenital cataract. The cytokine profiles are really different than those observed in senile cataract. Moreover, cytokines levels may be of interest to predict posterior capsule opacification and to complete the etiological workup.
BACKGROUND:Congenital cataract is of particular interest because of the variability of etiologies and the inflammatory reaction that are often observed. The aim of the study was to describe intraocular levels of various inflammation-related cytokines of patients with congenital cataract and to study their correlations with clinical determinants. METHODS: We followed a cohort of 18 patients (18 eyes) with congenital cataract from a University hospital and measured levels of various inflammation-related cytokines in the aqueous humor of patients with congenital cataract, and compared these levels to those observed in a control group (patients with senile cataract) using multiplex immunoassay. Correlation analysis was used to study the possible correlation between intraocular levels of cytokines and clinical determinants. RESULTS: Compared with the control group, the group with congenital cataract showed clear and significantly elevated concentrations of inflammatory markers (IL-1β, IL-15, IFN-γ, IL-12, IL-6, IL-5, IL-9, MIP-1α, MCP-1 and IP-10). Postoperative intraocular inflammation and opacification of the posterior capsule seemed to be correlated with preoperative IL-1β, TNF-α and IL-6 levels. CONCLUSIONS: An inflammatory condition may occur in eyes with congenital cataract. The cytokine profiles are really different than those observed in senile cataract. Moreover, cytokines levels may be of interest to predict posterior capsule opacification and to complete the etiological workup.