Tae-Dong Jeong1, Woochang Lee1, Yeo-Min Yun2, Sail Chun1, Junghan Song3, Won-Ki Min4. 1. Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea. 2. Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea. 3. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. 4. Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea. Electronic address: wkmin@amc.seoul.kr.
Abstract
BACKGROUND: The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was derived mostly from Caucasian, African-American, and Hispanic populations, whereas Asian populations were excluded. The aim of this study was to develop and validate a Korean version of the CKD-EPI equation. METHODS: The study enrolled 960 individuals 18years old and older who underwent chromium-51-ethylenediaminetetraacetic-acid-based glomerular filtration rate (GFR) measurements. They were divided randomly into two groups: a development set (n=768, 80%) and a validation set (n=192, 20%). The Korean CKD-EPI equation was developed using a non-linear mixed-effect model. The performance of the equation was evaluated by calculating the bias (estimated GFR-measured GFR). The ±10% (P10) and ±30% (P30) accuracies and root mean square errors (RMSEs) of the original and Korean CKD-EPI equations were compared. RESULTS: The Korean CKD-EPI equation was as follows: male, serum creatinine (Scr) ≤80μmol/L, GFR=141×(Scr/0.9)(-0.642)×(0.993)(Age); male, Scr>80μmol/L, GFR=141×(Scr/0.9)(-1.128)×(0.993)(Age); female, Scr≤62μmol/L, GFR=144×(Scr/0.7)(-0.465)×(0.993)(Age); female, Scr>62μmol/L, GFR=144×(Scr/0.7)(-1.382)×(0.993)(Age). The mean bias (mL/min/1.73m(2)) of the original CKD-EPI equation was -3.0±13.5 and that of the Korean CKD-EPI equation -2.3±13.3. The P10 and P30 of the original CKD-EPI equation were 33.9% and 82.8%; for the Korean CKD-EPI equation, the corresponding values were 35.4% and 85.9%. The RMSEs of the original and Korean CKD-EPI equations were 13.7 and 13.5, respectively. CONCLUSIONS: The overall analytical performance of the Korean CKD-EPI equation was equivalent to that of the original CKD-EPI equation. The original CKD-EPI equation is therefore also valid for the Korean population.
RCT Entities:
BACKGROUND: The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was derived mostly from Caucasian, African-American, and Hispanic populations, whereas Asian populations were excluded. The aim of this study was to develop and validate a Korean version of the CKD-EPI equation. METHODS: The study enrolled 960 individuals 18years old and older who underwent chromium-51-ethylenediaminetetraacetic-acid-based glomerular filtration rate (GFR) measurements. They were divided randomly into two groups: a development set (n=768, 80%) and a validation set (n=192, 20%). The Korean CKD-EPI equation was developed using a non-linear mixed-effect model. The performance of the equation was evaluated by calculating the bias (estimated GFR-measured GFR). The ±10% (P10) and ±30% (P30) accuracies and root mean square errors (RMSEs) of the original and Korean CKD-EPI equations were compared. RESULTS: The Korean CKD-EPI equation was as follows: male, serum creatinine (Scr) ≤80μmol/L, GFR=141×(Scr/0.9)(-0.642)×(0.993)(Age); male, Scr>80μmol/L, GFR=141×(Scr/0.9)(-1.128)×(0.993)(Age); female, Scr≤62μmol/L, GFR=144×(Scr/0.7)(-0.465)×(0.993)(Age); female, Scr>62μmol/L, GFR=144×(Scr/0.7)(-1.382)×(0.993)(Age). The mean bias (mL/min/1.73m(2)) of the original CKD-EPI equation was -3.0±13.5 and that of the Korean CKD-EPI equation -2.3±13.3. The P10 and P30 of the original CKD-EPI equation were 33.9% and 82.8%; for the Korean CKD-EPI equation, the corresponding values were 35.4% and 85.9%. The RMSEs of the original and Korean CKD-EPI equations were 13.7 and 13.5, respectively. CONCLUSIONS: The overall analytical performance of the Korean CKD-EPI equation was equivalent to that of the original CKD-EPI equation. The original CKD-EPI equation is therefore also valid for the Korean population.
Authors: Azrina Md Ralib; Farah Nadia Mohd Hanafiah; Iqbalmunawwir Abd Rashid; Mohamad Shahrir Abd Rahim; Fatimah Dzaharudin; Mohd Basri Mat Nor Journal: Int J Nephrol Date: 2021-09-08
Authors: Brechje J M V Huisman; Charles Agyemang; Bert-Jan H van den Born; Ron J G Peters; Marieke B Snijder; Liffert Vogt Journal: EClinicalMedicine Date: 2022-03-05
Authors: Misuk Ji; Yoon Hee Lee; Mina Hur; Hyesun Kim; Han Ik Cho; Hyun Suk Yang; Silvia Navarin; Salvatore Di Somma Journal: Ann Lab Med Date: 2016-11 Impact factor: 3.464