Junhong Leng1, Gongshu Liu2, Cuiping Zhang2, Shijuan Xin3, Fang Chen2, Baojuan Li2, Huiguang Tian2, Zhijie Yu4, Jaakko Tuomilehto5, Gang Hu6, Xilin Yang7. 1. Department of Epidemiology and BiostatisticsSchool of Public Health, Tianjin Medical University, Tianjin, China Tianjin Women and Children's Health CentreTianjin, China. 2. Tianjin Women and Children's Health CentreTianjin, China. 3. Tianjin Dong Li Women and Children's Health CentreTianjin, China. 4. Population Cancer Research Program and Department of PediatricsDalhousie University, Halifax, Nova Scotia, Canada. 5. Centre for Vascular PreventionDanube-University Krems, Krems, Austria Diabetes Prevention UnitNational Institute for Health and Welfare, Helsinki, Finland Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ)Madrid, Spain Diabetes Research GroupKing Abdulaziz University, Jeddah, Saudi Arabia. 6. Chronic Disease Epidemiology LaboratoryPennington Biomedical Research Center, Baton Rouge, Louisiana, USA. 7. Department of Epidemiology and BiostatisticsSchool of Public Health, Tianjin Medical University, Tianjin, China yangxilin@tmu.edu.cn yxl@hotmail.com.
Abstract
OBJECTIVE: Physical activity in a nonpregnant state or before pregnancy reduces the risk of type 2 diabetes and is also associated with reduced risk of gestational diabetes mellitus (GDM). However, it is uncertain whether physical activity during pregnancy reduces the risk of GDM. DESIGN AND METHODS: Using an established universal screening system in Tianjin, China, we prospectively recruited 11 450 pregnant women within the 12th gestational week from 2010 to 2012. These women underwent a 50-g 1-h glucose challenge test (GCT) at 24-28 weeks of gestation and a 75-g 2-h oral glucose tolerance test if GCT glucose ≥7.8mmol/L. GDM was defined according to the International Association of Diabetes and Pregnancy Study Group's criteria. Self-reported physical activity in the last month was collected at GCT time using a validated questionnaire. RESULTS: GDM developed in 7.3% (n=840) of the women. Women with GDM were less likely to be engaged in moderate-to-high physical activity during pregnancy than those without (79.8% vs 81.6%, P=0.191). Moderate-to-high physical activity during pregnancy was associated with decreased risk of GDM (multivariable odds ratio (OR): 0.81, 95% confidence interval (CI): 0.67-0.97). Sitting at home for 2-4h per day and >4h per day were associated with significantly increased risk of GDM (multivariable OR of sitting time for 2-4h vs <2h: 1.59, 95% CI: 1.18-2.15; OR of sitting time for >4h vs <2h: 1.73, 95% CI: 1.22-2.43). CONCLUSIONS: Increased physical activity during pregnancy was associated with reduced GDM risk, whereas sedentary lifestyle was associated with increased GDM risk among Chinese pregnant women.
OBJECTIVE: Physical activity in a nonpregnant state or before pregnancy reduces the risk of type 2 diabetes and is also associated with reduced risk of gestational diabetes mellitus (GDM). However, it is uncertain whether physical activity during pregnancy reduces the risk of GDM. DESIGN AND METHODS: Using an established universal screening system in Tianjin, China, we prospectively recruited 11 450 pregnant women within the 12th gestational week from 2010 to 2012. These women underwent a 50-g 1-h glucose challenge test (GCT) at 24-28 weeks of gestation and a 75-g 2-h oral glucose tolerance test if GCT glucose ≥7.8mmol/L. GDM was defined according to the International Association of Diabetes and Pregnancy Study Group's criteria. Self-reported physical activity in the last month was collected at GCT time using a validated questionnaire. RESULTS: GDM developed in 7.3% (n=840) of the women. Women with GDM were less likely to be engaged in moderate-to-high physical activity during pregnancy than those without (79.8% vs 81.6%, P=0.191). Moderate-to-high physical activity during pregnancy was associated with decreased risk of GDM (multivariable odds ratio (OR): 0.81, 95% confidence interval (CI): 0.67-0.97). Sitting at home for 2-4h per day and >4h per day were associated with significantly increased risk of GDM (multivariable OR of sitting time for 2-4h vs <2h: 1.59, 95% CI: 1.18-2.15; OR of sitting time for >4h vs <2h: 1.73, 95% CI: 1.22-2.43). CONCLUSIONS: Increased physical activity during pregnancy was associated with reduced GDM risk, whereas sedentary lifestyle was associated with increased GDM risk among Chinese pregnant women.
Authors: Si Gao; Junhong Leng; Xilin Yang; Hongyan Liu; Shuo Wang; Weiqin Li; Yue Wang; Gang Hu; Juliana C N Chan; Zhijie Yu; Hong Zhu Journal: BMJ Open Diabetes Res Care Date: 2020-04
Authors: Graciliano Ramos do Nascimento; Maria do Carmo Borges; José Natal Figueiroa; Lucas Victor Alves; João Guilherme Alves Journal: SAGE Open Med Date: 2019-09-09