Bente Morseth1, Sidsel Graff-Iversen2, Bjarne K Jacobsen3, Lone Jørgensen4, Audhild Nyrnes3, Dag S Thelle5, Peter Vestergaard6, Maja-Lisa Løchen7. 1. Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway School of Sport Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway Centre for Clinical Research and Education, University Hospital of North Norway Trust, Tromsø, Norway bente.morseth@uit.no. 2. Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway. 3. Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway. 4. Department of Health and Care Sciences, University of Tromsø, Tromsø, Norway Department of Clinical Therapeutic Services, University Hospital of Northern Norway, Tromsø, Norway. 5. Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway Department of Community Medicine and Public Health, Institute of Medicine, Gothenburg University, Gothenburg, Sweden. 6. Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark. 7. Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway Department of Cardiology, University Hospital of North Norway, Tromsø, Norway.
Abstract
AIMS: The objective was to examine the association of physical activity and resting heart rate (RHR) with hospital-diagnosed atrial fibrillation (AF) in a Norwegian cohort. METHODS AND RESULTS: This prospective study included 20 484 adults (50.3% men) who participated in the third Tromsø Study survey in 1986-87. At baseline, physical activity was assessed by a validated questionnaire, and RHR was objectively measured. Participants were followed from baseline through 2010 with respect to incident cases of hospital-diagnosed AF documented on an electrocardiogram. During a mean follow-up period of 20 years (409 045 person-years), 750 participants (70.5% men) were diagnosed with AF. Compared with the low physical activity group, moderately active individuals had a 19% lower risk of any AF [adjusted hazard ratio (HR) 0.81, 95% confidence interval (CI) 0.68-0.97], whereas highly active had similar risk of AF. Vigorously active individuals showed a non-significantly higher risk of AF (adjusted HR 1.37, 95% CI 0.77-2.43). Risk of AF increased with decreasing RHR (adjusted HR 0.92, 95% CI 0.86-0.98 for each 10 b.p.m. increase in RHR), and RHR < 50 b.p.m. was a risk factor for AF (P < 0.05). CONCLUSION: In this prospective cohort study, leisure time physical activity was associated with AF in a J-shaped pattern. Moderate physical activity was associated with a reduced risk of AF, whereas higher activity levels attenuated the benefits of moderate activity. Low RHR was a risk factor for AF. Our results support the hypothesis that moderate and vigorous physical activity may affect AF risk via different pathophysiological mechanisms. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: The objective was to examine the association of physical activity and resting heart rate (RHR) with hospital-diagnosed atrial fibrillation (AF) in a Norwegian cohort. METHODS AND RESULTS: This prospective study included 20 484 adults (50.3% men) who participated in the third Tromsø Study survey in 1986-87. At baseline, physical activity was assessed by a validated questionnaire, and RHR was objectively measured. Participants were followed from baseline through 2010 with respect to incident cases of hospital-diagnosed AF documented on an electrocardiogram. During a mean follow-up period of 20 years (409 045 person-years), 750 participants (70.5% men) were diagnosed with AF. Compared with the low physical activity group, moderately active individuals had a 19% lower risk of any AF [adjusted hazard ratio (HR) 0.81, 95% confidence interval (CI) 0.68-0.97], whereas highly active had similar risk of AF. Vigorously active individuals showed a non-significantly higher risk of AF (adjusted HR 1.37, 95% CI 0.77-2.43). Risk of AF increased with decreasing RHR (adjusted HR 0.92, 95% CI 0.86-0.98 for each 10 b.p.m. increase in RHR), and RHR < 50 b.p.m. was a risk factor for AF (P < 0.05). CONCLUSION: In this prospective cohort study, leisure time physical activity was associated with AF in a J-shaped pattern. Moderate physical activity was associated with a reduced risk of AF, whereas higher activity levels attenuated the benefits of moderate activity. Low RHR was a risk factor for AF. Our results support the hypothesis that moderate and vigorous physical activity may affect AF risk via different pathophysiological mechanisms. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Irene Grundvold; Per Torger Skretteberg; Knut Liestøl; Gunnar Erikssen; Kristian Engeseth; Knut Gjesdal; Sverre E Kjeldsen; Harald Arnesen; Jan Erikssen; Johan Bodegard Journal: Circ Arrhythm Electrophysiol Date: 2013-07-21
Authors: Anthony Aizer; J Michael Gaziano; Nancy R Cook; Joann E Manson; Julie E Buring; Christine M Albert Journal: Am J Cardiol Date: 2009-04-22 Impact factor: 2.778
Authors: M Myrstad; M-L Løchen; S Graff-Iversen; A K Gulsvik; D S Thelle; H Stigum; A H Ranhoff Journal: Scand J Med Sci Sports Date: 2013-11-21 Impact factor: 4.221
Authors: Nabil Ghorayeb; Ricardo Stein; Daniel Jogaib Daher; Anderson Donelli da Silveira; Luiz Eduardo Fonteles Ritt; Daniel Fernando Pellegrino Dos Santos; Ana Paula Rennó Sierra; Artur Haddad Herdy; Claúdio Gil Soares de Araújo; Cléa Simone Sabino de Souza Colombo; Daniel Arkader Kopiler; Filipe Ferrari Ribeiro de Lacerda; José Kawazoe Lazzoli; Luciana Diniz Nagem Janot de Matos; Marcelo Bichels Leitão; Ricardo Contesini Francisco; Rodrigo Otávio Bougleux Alô; Sérgio Timerman; Tales de Carvalho; Thiago Ghorayeb Garcia Journal: Arq Bras Cardiol Date: 2019-03 Impact factor: 2.000
Authors: David A McNamara; Norman Aiad; Erin Howden; Michinari Hieda; Mark S Link; Dean Palmer; Mitchel Samels; Braden Everding; Jason Ng; Beverley Adams-Huet; Mildred Opondo; Satyam Sarma; Benjamin D Levine Journal: Circulation Date: 2019-03-19 Impact factor: 29.690
Authors: Adrian D Elliott; Rajiv Mahajan; Dominik Linz; Michael Stokes; Christian V Verdicchio; Melissa E Middeldorp; Andre La Gerche; Dennis H Lau; Prashanthan Sanders Journal: Clin Cardiol Date: 2018-06-12 Impact factor: 2.882
Authors: Osmar Antonio Centurión; José C Candia; Karina E Scavenius; Laura B García; Judith M Torales; Luís Marcelo Miño Journal: J Atr Fibrillation Date: 2019-10-31
Authors: Nancy Luo; Peter Merrill; Kishan S Parikh; David J Whellan; Ileana L Piña; Mona Fiuzat; William E Kraus; Dalane W Kitzman; Steven J Keteyian; Christopher M O'Connor; Robert J Mentz Journal: J Am Coll Cardiol Date: 2017-04-04 Impact factor: 24.094