Literature DB >> 26965961

'Mitotherapy' for Heart Failure.

Fabian Sanchis-Gomar1, Giuseppe Lippi2, Alejandro Lucia3.   

Abstract

Abnormalities in mitochondrial dynamics along with those for the molecular mediators involved are presently being viewed with increased interest in the field of cardiovascular disease. Recent research highlights OPA1, a dynamin-like GTPase mediating mitochondrial fusion, as well as the 'mitoproteases' OMA1 and YME1L, as potential therapeutic targets against heart failure.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  aging; heart; pathway

Mesh：

Year:  2016        PMID： 26965961     DOI： 10.1016/j.molmed.2016.02.007

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  3 in total

1.  Indomethacin impairs mitochondrial dynamics by activating the PKCζ-p38-DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells.

Authors:  Somnath Mazumder; Rudranil De; Subhashis Debsharma; Samik Bindu; Pallab Maity; Souvik Sarkar; Shubhra Jyoti Saha; Asim Azhar Siddiqui; Chinmoy Banerjee; Shiladitya Nag; Debanjan Saha; Saikat Pramanik; Kalyan Mitra; Uday Bandyopadhyay
Journal:  J Biol Chem       Date:  2019-04-02       Impact factor: 5.157

2.  Novel super-resolution capable mitochondrial probe, MitoRed AIE, enables assessment of real-time molecular mitochondrial dynamics.

Authors:  Camden Yeung-Wah Lo; Sijie Chen; Sarah Jayne Creed; Miaomiao Kang; Na Zhao; Ben Zhong Tang; Kirstin Diana Elgass
Journal:  Sci Rep       Date:  2016-08-05       Impact factor: 4.379

3.  GDF11 enhances therapeutic efficacy of mesenchymal stem cells for myocardial infarction via YME1L-mediated OPA1 processing.

Authors:  Yun Zhao; Jinyun Zhu; Ning Zhang; Qi Liu; Yingchao Wang; Xinyang Hu; Jinghai Chen; Wei Zhu; Hong Yu
Journal:  Stem Cells Transl Med       Date:  2020-06-09       Impact factor: 6.940
  3 in total

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