Susana Boronat1,2, Ignasi Barber3, Vivek Pargaonkar4, Joshua Chang1, Elizabeth A Thiele5. 1. Department of Neurology, Massachusetts General Hospital, 175 Cambridge Street, Suite 340, Boston, MA, USA. 2. Department of Pediatric Neurology, Vall d'Hebron Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain. 3. Department of Pediatric Radiology, Vall d' Hebron Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain. 4. Department of Radiology, Massachusetts General Hospital, Boston, MA, USA. 5. Department of Neurology, Massachusetts General Hospital, 175 Cambridge Street, Suite 340, Boston, MA, USA. ethiele@partners.org.
Abstract
BACKGROUND: Sclerotic bone lesions are often seen on chest CT in adults with tuberous sclerosis complex. OBJECTIVE: To characterize bone lesions at abdominal MRI in children with tuberous sclerosis complex. MATERIALS AND METHODS: This retrospective review included 70 children with tuberous sclerosis complex who had undergone abdominal MRI for renal imaging. An additional longitudinal study was performed in 50 children who had had two or more MRI scans. Abdominal CT (eight children) and radiographs (three children) were reviewed and compared with MRI. RESULTS: A total of 173 sclerotic bone lesions were detected in 51/70 children (73%; 95% confidence interval: 0.61-0.82) chiefly affecting vertebral pedicles. New lesions appeared in 20 children and growth of previous sclerotic bone lesions was documented in 14 children. Sclerotic bone lesions were more frequent in girls and in children with more extensive renal involvement. CONCLUSION: Sclerotic bone lesions are commonly detected by abdominal MRI in children with tuberous sclerosis complex. They usually affect posterior vertebral elements and their number and size increase with age. As current recommendations for tuberous sclerosis complex surveillance include renal MR performed in childhood, recognition of these lesions is useful.
BACKGROUND:Sclerotic bone lesions are often seen on chest CT in adults with tuberous sclerosis complex. OBJECTIVE: To characterize bone lesions at abdominal MRI in children with tuberous sclerosis complex. MATERIALS AND METHODS: This retrospective review included 70 children with tuberous sclerosis complex who had undergone abdominal MRI for renal imaging. An additional longitudinal study was performed in 50 children who had had two or more MRI scans. Abdominal CT (eight children) and radiographs (three children) were reviewed and compared with MRI. RESULTS: A total of 173 sclerotic bone lesions were detected in 51/70 children (73%; 95% confidence interval: 0.61-0.82) chiefly affecting vertebral pedicles. New lesions appeared in 20 children and growth of previous sclerotic bone lesions was documented in 14 children. Sclerotic bone lesions were more frequent in girls and in children with more extensive renal involvement. CONCLUSION:Sclerotic bone lesions are commonly detected by abdominal MRI in children with tuberous sclerosis complex. They usually affect posterior vertebral elements and their number and size increase with age. As current recommendations for tuberous sclerosis complex surveillance include renal MR performed in childhood, recognition of these lesions is useful.
Entities:
Keywords:
Bone; Children; Magnetic resonance imaging; Sclerotic bone lesions; Tuberous sclerosis complex
Authors: Fang Fang; Shaogang Sun; Li Wang; Jun-Lin Guan; Marco Giovannini; Yuan Zhu; Fei Liu Journal: J Bone Miner Res Date: 2015-07 Impact factor: 6.741