Literature DB >> 26965133

Optogenetic Engineering of Atrial Cardiomyocytes.

Iolanda Feola1, Alexander Teplenin1, Antoine A F de Vries1,2, Daniël A Pijnappels3.   

Abstract

Optogenetics is emerging in the cardiology field as a new strategy to explore biological functions through the use of light-sensitive proteins and dedicated light sources. For example, this technology allows modification of the electrophysiological properties of cardiac muscle cells with superb spatiotemporal resolution and quantitative control. In this chapter, the optogenetic modification of atrial cardiomyocytes (aCMCs) from 2-day-old Wistar rats using lentiviral vector (LV) technology and the subsequent activation of the light-sensitive proteins (i.e., ion channels) through light-emitting diodes (LEDs) are described.

Entities:  

Keywords:  Atrial cardiomyocytes; Lentiviral vectors; Light-emitting diode (LED); Optical mapping; Optogenetics

Mesh：

Substances：

Year:  2016        PMID： 26965133     DOI： 10.1007/978-1-4939-3512-3_22

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  6 in total

Review 1.  Cardiac optogenetics: a decade of enlightenment.

Authors:  Emilia Entcheva; Matthew W Kay
Journal:  Nat Rev Cardiol       Date:  2020-12-18       Impact factor: 32.419

2.  Paradoxical Onset of Arrhythmic Waves from Depolarized Areas in Cardiac Tissue Due to Curvature-Dependent Instability.

Authors:  Alexander S Teplenin; Hans Dierckx; Antoine A F de Vries; Daniël A Pijnappels; Alexander V Panfilov
Journal:  Phys Rev X       Date:  2018-06-26       Impact factor: 15.762

3.  Generation and primary characterization of iAM-1, a versatile new line of conditionally immortalized atrial myocytes with preserved cardiomyogenic differentiation capacity.

Authors:  Jia Liu; Linda Volkers; Wanchana Jangsangthong; Cindy I Bart; Marc C Engels; Guangqian Zhou; Martin J Schalij; Dirk L Ypey; Daniël A Pijnappels; Antoine A F de Vries
Journal:  Cardiovasc Res       Date:  2018-12-01       Impact factor: 10.787

4.  Termination of re-entrant atrial tachycardia via optogenetic stimulation with optimized spatial targeting: insights from computational models.

Authors:  Patrick M Boyle; Michael J Murphy; Thomas V Karathanos; Sohail Zahid; Robert C Blake; Natalia A Trayanova
Journal:  J Physiol       Date:  2017-12-28       Impact factor: 5.182

5.  Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating.

Authors:  Rupamanjari Majumder; Tim De Coster; Nina Kudryashova; Alexander V Panfilov; Daniël A Pijnappels; Arie O Verkerk; Ivan V Kazbanov; Balázs Ördög; Niels Harlaar; Ronald Wilders; Antoine Af de Vries; Dirk L Ypey
Journal:  Elife       Date:  2020-06-08       Impact factor: 8.140

Review 6.  Multicellular In vitro Models of Cardiac Arrhythmias: Focus on Atrial Fibrillation.

Authors:  Pim R R van Gorp; Serge A Trines; Daniël A Pijnappels; Antoine A F de Vries
Journal:  Front Cardiovasc Med       Date:  2020-03-31
  6 in total

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