Noorsuzana Mohd Shariff1, Nazarudin Safian2. 1. Infectious Disease Cluster, Advanced Medical and Dental Institute, University of Science Malaysia, Pulau Pinang, Malaysia; Department of Community Health, National University of Malaysia Medical Center, Jalan Yaacob Latiff, Kuala Lumpur, Malaysia. Electronic address: suzana_1910@yahoo.com. 2. Department of Community Health, National University of Malaysia Medical Center, Jalan Yaacob Latiff, Kuala Lumpur, Malaysia.
Abstract
OBJECTIVE/ BACKGROUND: Many studies have suggested that sputum smear conversion after 2 months of antituberculosis treatment is an important determinant of treatment success and can be a predictor for relapse. The objective of this study is to determine the factors that influence sputum smear conversion after 2 months of treatment among pulmonary tuberculosis patients receiving treatment in the Institute of Respiratory Medicine in Kuala Lumpur, Malaysia. METHODS: A total of 75 cases and 75 controls were interviewed, and their medical records were retrieved in order to extract the information needed. All analyses were conducted using SPSS version 17, and binary logistic regression analysis was used to determine the predictors of sputum smear nonconversion. RESULTS: Results showed that the following factors were associated with sputum smear positivity after 2 months of intensive treatment: diabetes mellitus (p=.013, odds ratio [OR]=2.59, 95% confidence interval [CI] 1.27-5.33), underweight body mass index (p=.025, OR=1.67, 95% CI 0.80-3.49), nonadherent to tuberculosis treatment (p=.024, OR=2.85, 95% CI 1.21-6.74), and previous history of tuberculosis (p=.043, OR=2.53, 95% CI 1.09-5.83). Multivariable analysis identified diabetes mellitus (p=.003, OR=4.01, 95% CI 1.61-9.96) as being independently associated with the risk of persistent sputum smear positivity after 2 months of intensive treatment. CONCLUSION: Based on the findings, identification of these factors is valuable in strengthening the management and treatment of tuberculosis in Malaysia in the future. This study emphasizes the importance of diabetes screening and integration of diabetic controls among tuberculosis patients in achieving better treatment outcome.
OBJECTIVE/ BACKGROUND: Many studies have suggested that sputum smear conversion after 2 months of antituberculosis treatment is an important determinant of treatment success and can be a predictor for relapse. The objective of this study is to determine the factors that influence sputum smear conversion after 2 months of treatment among pulmonary tuberculosispatients receiving treatment in the Institute of Respiratory Medicine in Kuala Lumpur, Malaysia. METHODS: A total of 75 cases and 75 controls were interviewed, and their medical records were retrieved in order to extract the information needed. All analyses were conducted using SPSS version 17, and binary logistic regression analysis was used to determine the predictors of sputum smear nonconversion. RESULTS: Results showed that the following factors were associated with sputum smear positivity after 2 months of intensive treatment: diabetes mellitus (p=.013, odds ratio [OR]=2.59, 95% confidence interval [CI] 1.27-5.33), underweight body mass index (p=.025, OR=1.67, 95% CI 0.80-3.49), nonadherent to tuberculosis treatment (p=.024, OR=2.85, 95% CI 1.21-6.74), and previous history of tuberculosis (p=.043, OR=2.53, 95% CI 1.09-5.83). Multivariable analysis identified diabetes mellitus (p=.003, OR=4.01, 95% CI 1.61-9.96) as being independently associated with the risk of persistent sputum smear positivity after 2 months of intensive treatment. CONCLUSION: Based on the findings, identification of these factors is valuable in strengthening the management and treatment of tuberculosis in Malaysia in the future. This study emphasizes the importance of diabetes screening and integration of diabetic controls among tuberculosispatients in achieving better treatment outcome.
Authors: Eun Hye Lee; Jung Mo Lee; Young Ae Kang; Ah Young Leem; Eun Young Kim; Ji Ye Jung; Moo Suk Park; Young Sam Kim; Se Kyu Kim; Joon Chang; Song Yee Kim Journal: Lung Date: 2017-02-09 Impact factor: 2.584
Authors: Kattya Lopez; María B Arriaga; Juan G Aliaga; Nadia N Barreda; Oswaldo M Sanabria; Chuan-Chin Huang; Zibiao Zhang; Ruth García-de-la-Guarda; Leonid Lecca; Anna Cristina Calçada Carvalho; Afrânio L Kritski; Roger I Calderon Journal: PLoS One Date: 2021-01-28 Impact factor: 3.240