Literature DB >> 26959181

AMPK Promotes Autophagy by Facilitating Mitochondrial Fission.

Chen-Song Zhang1, Sheng-Cai Lin2.   

Abstract

AMPK senses decreased cellular energy levels, triggering mitochondrial autophagy or mitophagy through activating ULK1 and inhibiting mTORC1. In a recent report, Toyama et al. (2016) show that activated AMPK phosphorylation of MFF is critical for mitochondrial fission. Unphosphorylatable MFF mutants block mitophagy, connecting AMPK to mitochondrial fission and to mitophagy.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 26959181     DOI： 10.1016/j.cmet.2016.02.017

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


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