Alexander Carr1, Anthony J Doyle2, Nicola Dalbeth3, Opetaia Aati3, Fiona M McQueen1,4. 1. 1 Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand. 2. 2 Department of Radiology, Auckland City Hospital, Auckland District Health Board, Auckland, New Zealand. 3. 3 Department of Medicine, Bone and Joint Research Group, University of Auckland, Auckland, New Zealand. 4. 4 Department of Rheumatology, Greenlane Clinical Centre, Auckland District Health Board, Auckland, New Zealand.
Abstract
OBJECTIVE: The purpose of this study was to investigate whether monosodium urate (MSU) deposits could be identified within the abdomen and axial skeleton of patients with tophaceous gout using dual-energy CT (DECT). CONCLUSION: DECT of the abdomen, chest wall, and spine revealed extensive MSU deposits in costal cartilages and, to a lesser extent, intervertebral disks in the male patients with gout in our study. These were quantified volumetrically. However, age-matched control subjects showed similar deposits, indicating this was not a disease-specific finding. Thus, MSU deposition in the axial skeleton may be physiologic in middle-aged men.
OBJECTIVE: The purpose of this study was to investigate whether monosodium urate (MSU) deposits could be identified within the abdomen and axial skeleton of patients with tophaceous gout using dual-energy CT (DECT). CONCLUSION: DECT of the abdomen, chest wall, and spine revealed extensive MSU deposits in costal cartilages and, to a lesser extent, intervertebral disks in the male patients with gout in our study. These were quantified volumetrically. However, age-matched control subjects showed similar deposits, indicating this was not a disease-specific finding. Thus, MSU deposition in the axial skeleton may be physiologic in middle-aged men.
Authors: Penny Wang; Stacy E Smith; Rajesh Garg; Fengxin Lu; Alyssa Wohlfahrt; Anarosa Campos; Kathleen Vanni; Zhi Yu; Daniel H Solomon; Seoyoung C Kim Journal: RMD Open Date: 2018-03-09