Literature DB >> 26957497

Primary Care Physician Perspectives on Hepatitis C Management in the Era of Direct-Acting Antiviral Therapy.

Mary Thomson1, Monica A Konerman2, Hetal Choxi3, Anna S F Lok4.   

Abstract

BACKGROUND: Primary care physicians (PCPs) play a critical role in the care cascade for patients with chronic hepatitis C (CHC). AIM: To assess PCP knowledge and perspectives on CHC screening, diagnosis, referral, and treatment.
METHODS: An anonymous survey was distributed to PCPs who participated in routine outpatient care at our hospital.
RESULTS: Eighty (36 %) eligible PCPs completed the survey. More than half were females (60 %) aged 36-50 (55 %) from family (44 %) or internal (49 %) medicine. Overall, PCPs correctly identified high-risk populations for screening, though 19 % failed to identify baby boomers and 45 % failed to identify hemodialysis patients as populations to screen. Approximately half reported they were able to screen at risk patients <50 % of the time secondary to time constraints and difficulty assessing if patients had already been screened. 71 % of PCPs reported they refer all newly diagnosed patients to specialty care. 70 % of PCPs did not feel up to date with current treatment. The majority grossly underestimated efficacy, tolerability and ease of administration, and overestimated treatment duration. Only 9 % felt comfortable treating CHC, even those without cirrhosis. Practice patterns were influenced by specialty and Veterans Affairs Hospital affiliation.
CONCLUSIONS: Although the majority of PCPs are up to date with CHC screening recommendations, few are able to routinely screen in practice. Most PCPs are not up to date with treatment and do not feel comfortable treating CHC. Interventions to overcome screening barriers and expand treatment into primary care settings are needed to maximize access to and use of curative therapies.

Entities:  

Keywords:  General practice; Guidelines; Hepatitis C; Screening

Mesh:

Substances:

Year:  2016        PMID: 26957497      PMCID: PMC5729045          DOI: 10.1007/s10620-016-4097-2

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN: 0163-2116            Impact factor:   3.199


  18 in total

1.  Outcomes of treatment for hepatitis C virus infection by primary care providers.

Authors:  Sanjeev Arora; Karla Thornton; Glen Murata; Paulina Deming; Summers Kalishman; Denise Dion; Brooke Parish; Thomas Burke; Wesley Pak; Jeffrey Dunkelberg; Martin Kistin; John Brown; Steven Jenkusky; Miriam Komaromy; Clifford Qualls
Journal:  N Engl J Med       Date:  2011-06-01       Impact factor: 91.245

2.  Hepatitis C in the United States.

Authors:  Scott D Holmberg; Philip R Spradling; Anne C Moorman; Maxine M Denniston
Journal:  N Engl J Med       Date:  2013-05-16       Impact factor: 91.245

3.  Primary care-based interventions are associated with increases in hepatitis C virus testing for patients at risk.

Authors:  Alain H Litwin; Bryce D Smith; Mari-Lynn Drainoni; Diane McKee; Allen L Gifford; Elisa Koppelman; Cindy L Christiansen; Cindy M Weinbaum; William N Southern
Journal:  Dig Liver Dis       Date:  2012-02-18       Impact factor: 4.088

4.  ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV.

Authors:  Peter Ferenci; David Bernstein; Jacob Lalezari; Daniel Cohen; Yan Luo; Curtis Cooper; Edward Tam; Rui T Marinho; Naoky Tsai; Anders Nyberg; Terry D Box; Ziad Younes; Pedram Enayati; Sinikka Green; Yaacov Baruch; Bal Raj Bhandari; Florin Alexandru Caruntu; Thomas Sepe; Vladimir Chulanov; Ewa Janczewska; Giuliano Rizzardini; Judit Gervain; Ramon Planas; Christophe Moreno; Tarek Hassanein; Wangang Xie; Martin King; Thomas Podsadecki; K Rajender Reddy
Journal:  N Engl J Med       Date:  2014-05-04       Impact factor: 91.245

5.  Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945-1965.

Authors:  Bryce D Smith; Rebecca L Morgan; Geoff A Beckett; Yngve Falck-Ytter; Deborah Holtzman; Chong-Gee Teo; Amy Jewett; Brittney Baack; David B Rein; Nita Patel; Miriam Alter; Anthony Yartel; John W Ward
Journal:  MMWR Recomm Rep       Date:  2012-08-17

6.  Hepatitis C identification and management by family physicians.

Authors:  Elizabeth C Clark; Barbara P Yawn; James M Galliher; Jonathan L Temte; John Hickner
Journal:  Fam Med       Date:  2005-10       Impact factor: 1.756

Review 7.  Chronic hepatitis C: an age wave of disease burden.

Authors:  John G McHutchison; Bruce R Bacon
Journal:  Am J Manag Care       Date:  2005-10       Impact factor: 2.229

8.  The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007.

Authors:  Kathleen N Ly; Jian Xing; R Monina Klevens; Ruth B Jiles; John W Ward; Scott D Holmberg
Journal:  Ann Intern Med       Date:  2012-02-21       Impact factor: 25.391

9.  Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection.

Authors:  Nezam Afdhal; Stefan Zeuzem; Paul Kwo; Mario Chojkier; Norman Gitlin; Massimo Puoti; Manuel Romero-Gomez; Jean-Pierre Zarski; Kosh Agarwal; Peter Buggisch; Graham R Foster; Norbert Bräu; Maria Buti; Ira M Jacobson; G Mani Subramanian; Xiao Ding; Hongmei Mo; Jenny C Yang; Phillip S Pang; William T Symonds; John G McHutchison; Andrew J Muir; Alessandra Mangia; Patrick Marcellin
Journal:  N Engl J Med       Date:  2014-04-11       Impact factor: 91.245

10.  An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases.

Authors:  Marc G Ghany; David R Nelson; Doris B Strader; David L Thomas; Leonard B Seeff
Journal:  Hepatology       Date:  2011-09-26       Impact factor: 17.425

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  16 in total

Review 1.  Challenges Facing a Rural Opioid Epidemic: Treatment and Prevention of HIV and Hepatitis C.

Authors:  Asher J Schranz; Jessica Barrett; Christopher B Hurt; Carlos Malvestutto; William C Miller
Journal:  Curr HIV/AIDS Rep       Date:  2018-06       Impact factor: 5.071

2.  Going Viral: Why Eliminating the Burden of Hepatitis C Requires Enhanced Cooperation Between Specialists and Primary Care Providers.

Authors:  Rena Fox
Journal:  Dig Dis Sci       Date:  2016-12       Impact factor: 3.199

3.  Barriers to Treatment Access for Chronic Hepatitis C Virus Infection: A Case Series.

Authors:  Alexander J Millman; Boatemaa Ntiri-Reid; Risha Irvin; Maggie H Kaufmann; Andrew Aronsohn; Jeffrey S Duchin; John D Scott; Claudia Vellozzi
Journal:  Top Antivir Med       Date:  2017 Jul/Aug

4.  Patterns of practice and barriers to care for hepatitis C in the direct-acting antiviral (DAA) era: A national survey of Canadian infectious diseases physicians.

Authors:  Justin Chan; Jim Young; Joseph Cox; Roy Nitulescu; Marina B Klein
Journal:  Can Liver J       Date:  2018-12-25

5.  CDC Screening Recommendation for Baby Boomers and Hepatitis C Virus Testing in the US Military Health System.

Authors:  Janna Manjelievskaia; Derek Brown; Craig D Shriver; Kangmin Zhu
Journal:  Public Health Rep       Date:  2017-08-02       Impact factor: 2.792

6.  Educating Primary Care Providers and Associate Care Providers About Hepatitis C Screening of Baby Boomers: a Multi-practice Study.

Authors:  Bertha E Flores; Andrea A Fernandez; Chen-Pin Wang; Raudel Bobadilla; Ludivina Hernandez; Mamta K Jain; Barbara J Turner
Journal:  J Cancer Educ       Date:  2022-02       Impact factor: 2.037

7.  A Hepatitis C Educational Needs Assessment of Canadian Healthcare Providers.

Authors:  Reza Naghdi; Karen Seto; Carolyn Klassen; Didi Emokpare; Brian Conway; Melissa Kelley; Eric Yoshida; Hemant A Shah
Journal:  Can J Gastroenterol Hepatol       Date:  2017-03-15

8.  Association of the Extension for Community Healthcare Outcomes Project With Use of Direct-Acting Antiviral Treatment Among US Adults With Hepatitis C.

Authors:  Linh Tran; Roger Feldman; Thomas Riley; Jeah Jung
Journal:  JAMA Netw Open       Date:  2021-07-01

9.  Hepatitis C Treatment and Barriers to Eradication.

Authors:  Monica A Konerman; Anna S F Lok
Journal:  Clin Transl Gastroenterol       Date:  2016-09-22       Impact factor: 4.488

10.  Effect of a Cooperation Strategy between Primary Care Physicians and Hospital Liver Units on HBV Care in Campania, Italy.

Authors:  Rosa Zampino; Nicolina Capoluongo; Adriana Boemio; Margherita Macera; Martina Vitrone; Luigi Elio Adinolfi; Pietro Filippini; Evangelista Sagnelli; Caterina Sagnelli; Emanuele Durante-Mangoni; Nicola Coppola
Journal:  Can J Gastroenterol Hepatol       Date:  2018-07-26
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