Literature DB >> 26957024

Understanding the effect of the nature of the nucleobase in the loops on the stability of the i-motif structure.

Sanae Benabou1, Miguel Garavís2, Sébastien Lyonnais3, Ramon Eritja4, Carlos González5, Raimundo Gargallo6.   

Abstract

The nature and the length of loops connecting cytosine tracts in i-motif structures may affect their stability. In this work, the influence of the nature of the nucleobases located in two of the loops of an intramolecular i-motif is studied using spectroscopy, separation techniques, and multivariate data analysis. The insertion of bases other than thymine induces an additional acid-base equilibrium with pKa ∼ 4.5. The presence of two guanine bases in the loops, placed opposite to each other, decreases the thermal stability of the structure. In contrast, thymine and cytosine bases in these positions stabilize the structure.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 26957024     DOI： 10.1039/c5cp07428b

Source DB:  PubMed          Journal:  Phys Chem Chem Phys        ISSN： 1463-9076            Impact factor:   3.676


  10 in total

1.  Unusual Isothermal Hysteresis in DNA i-Motif pH Transitions: A Study of the RAD17 Promoter Sequence.

Authors:  R Aaron Rogers; Aaron M Fleming; Cynthia J Burrows
Journal:  Biophys J       Date:  2018-04-24       Impact factor: 4.033

2.  Study of conformational transitions of i-motif DNA using time-resolved fluorescence and multivariate analysis methods.

Authors:  Sanae Benabou; Cyril Ruckebusch; Michel Sliwa; Anna Aviñó; Ramon Eritja; Raimundo Gargallo; Anna de Juan
Journal:  Nucleic Acids Res       Date:  2019-07-26       Impact factor: 16.971

3.  Rapid Screen of Potential i-Motif Forming Sequences in DNA Repair Gene Promoters.

Authors:  R Aaron Rogers; Aaron M Fleming; Cynthia J Burrows
Journal:  ACS Omega       Date:  2018-08-21

4.  i-Motif DNA: structural features and significance to cell biology.

Authors:  Hala Abou Assi; Miguel Garavís; Carlos González; Masad J Damha
Journal:  Nucleic Acids Res       Date:  2018-09-19       Impact factor: 16.971

5.  Systematic investigation of sequence requirements for DNA i-motif formation.

Authors:  Petra Školáková; Daniel Renčiuk; Jan Palacký; Daniel Krafčík; Zuzana Dvořáková; Iva Kejnovská; Klára Bednářová; Michaela Vorlíčková
Journal:  Nucleic Acids Res       Date:  2019-03-18       Impact factor: 16.971

6.  pH-driven conformational switch between non-canonical DNA structures in a C-rich domain of EGFR promoter.

Authors:  Camilla Cristofari; Riccardo Rigo; Maria Laura Greco; Michele Ghezzo; Claudia Sissi
Journal:  Sci Rep       Date:  2019-02-04       Impact factor: 4.379

7.  MD-TSPC4: Computational Method for Predicting the Thermal Stability of I-Motif.

Authors:  Amen Shamim; Maria Razzaq; Kyeong Kyu Kim
Journal:  Int J Mol Sci       Date:  2020-12-23       Impact factor: 5.923

8.  i-Motif of cytosine-rich human telomere DNA fragments containing natural base lesions.

Authors:  Zuzana Dvoráková; Daniel Renciuk; Iva Kejnovská; Petra Školáková; Klára Bednárová; Janos Sagi; Michaela Vorlícková
Journal:  Nucleic Acids Res       Date:  2018-02-28       Impact factor: 16.971

9.  A dynamic i-motif with a duplex stem-loop in the long terminal repeat promoter of the HIV-1 proviral genome modulates viral transcription.

Authors:  Emanuela Ruggiero; Sara Lago; Primož Šket; Matteo Nadai; Ilaria Frasson; Janez Plavec; Sara N Richter
Journal:  Nucleic Acids Res       Date:  2019-12-02       Impact factor: 16.971

10.  Structure of i-Motif/Duplex Junctions at Neutral pH.

Authors:  Israel Serrano-Chacón; Bartomeu Mir; Núria Escaja; Carlos González
Journal:  J Am Chem Soc       Date:  2021-08-09       Impact factor: 15.419
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.