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Literature DB >> 26956002

Detection of Sulfatase Enzyme Activity with a CatalyCEST MRI Contrast Agent.

Sanhita Sinharay¹, Gabriela Fernández-Cuervo², Jasmine P Acfalle¹, Mark D Pagel³.

Abstract

A chemical exchange saturation transfer (CEST) MRI contrast agent has been developed that detects sulfatase enzyme activity. The agent produces a CEST signal at δ=5.0 ppm before enzyme activity, and a second CEST signal appears at δ=9.0 ppm after the enzyme cleaves a sulfate group from the agent. The comparison of the two signals improved detection of sulfatase activity.

Entities: CellLine Chemical Disease Gene Species

Keywords: NMR imaging; diagnostic agents; enzyme kinetics; kinetics; sulfatases

Mesh：

Substances：
Contrast Media
Sulfatases

Year: 2016 PMID： 26956002 PMCID： PMC4877021 DOI： 10.1002/chem.201600685

Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236

23 in total

1. On the origin of cancer cells.

Authors: O WARBURG
Journal: Science Date: 1956-02-24 Impact factor: 47.728

2. Detection of enzymatic activity by PARACEST MRI: a general approach to target a large variety of enzymes.

Authors: Thomas Chauvin; Philippe Durand; Michèle Bernier; Hervé Meudal; Bich-Thuy Doan; Fanny Noury; Bernard Badet; Jean-Claude Beloeil; Eva Tóth
Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336

3. A self-calibrating PARACEST MRI contrast agent that detects esterase enzyme activity.

Authors: Yuguo Li; Vipul R Sheth; Guanshu Liu; Mark D Pagel
Journal: Contrast Media Mol Imaging Date: 2010-11-30 Impact factor: 3.161

4. Comparative cytotoxicity of 5-aminosalicylic acid (mesalazine) and related compounds in different cell lines.

Authors: E Noble; L Janssen; P J Dierickx
Journal: Cell Biol Toxicol Date: 1997-10 Impact factor: 6.691

Review 5. Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility.

Authors: Sarah R Hanson; Michael D Best; Chi-Huey Wong
Journal: Angew Chem Int Ed Engl Date: 2004-11-05 Impact factor: 15.336

6. Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI.

Authors: Jikun Li; Xinxin Feng; Wei Zhu; Nikita Oskolkov; Tianhui Zhou; Boo Kyung Kim; Noman Baig; Michael T McMahon; Eric Oldfield
Journal: Chemistry Date: 2015-11-30 Impact factor: 5.236

7. The reciprocal linear QUEST analysis method facilitates the measurements of chemical exchange rates with CEST MRI.

Authors: Edward A Randtke; Liu Qi Chen; Mark D Pagel
Journal: Contrast Media Mol Imaging Date: 2014 May-Jun Impact factor: 3.161

8. The Hanes-Woolf linear QUESP method improves the measurements of fast chemical exchange rates with CEST MRI.

Authors: Edward A Randtke; Liu Qi Chen; L Rene Corrales; Mark D Pagel
Journal: Magn Reson Med Date: 2013-06-18 Impact factor: 4.668

9. Bioluminescent probes of sulfatase activity.

Authors: Jason S Rush; Kimberly E Beatty; Carolyn R Bertozzi
Journal: Chembiochem Date: 2010-10-18 Impact factor: 3.164

10. Sulfatase 2 promotes breast cancer progression through regulating some tumor-related factors.

Authors: Chenfang Zhu; Liu He; Xin Zhou; Xin Nie; Yan Gu
Journal: Oncol Rep Date: 2015-12-28 Impact factor: 3.906

6 in total

Review 1. Clinical applications of chemical exchange saturation transfer (CEST) MRI.

Authors: Kyle M Jones; Alyssa C Pollard; Mark D Pagel
Journal: J Magn Reson Imaging Date: 2017-08-09 Impact factor: 4.813

2. Detecting acid phosphatase enzymatic activity with phenol as a chemical exchange saturation transfer magnetic resonance imaging contrast agent (PhenolCEST MRI).

Authors: Jia Zhang; Yue Yuan; Zheng Han; Yuguo Li; Peter C M van Zijl; Xing Yang; Jeff W M Bulte; Guanshu Liu
Journal: Biosens Bioelectron Date: 2019-06-20 Impact factor: 10.618

Review 6. Probing Reversible Guest Binding with Hyperpolarized ¹²⁹Xe-NMR: Characteristics and Applications for Cucurbit[n]urils.

Authors: Jabadurai Jayapaul; Leif Schröder
Journal: Molecules Date: 2020-02-20 Impact factor: 4.411

6 in total

Detection of Sulfatase Enzyme Activity with a CatalyCEST MRI Contrast Agent.

1. On the origin of cancer cells.

2. Detection of enzymatic activity by PARACEST MRI: a general approach to target a large variety of enzymes.

3. A self-calibrating PARACEST MRI contrast agent that detects esterase enzyme activity.

4. Comparative cytotoxicity of 5-aminosalicylic acid (mesalazine) and related compounds in different cell lines.

Review 5. Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility.

6. Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI.

7. The reciprocal linear QUEST analysis method facilitates the measurements of chemical exchange rates with CEST MRI.

8. The Hanes-Woolf linear QUESP method improves the measurements of fast chemical exchange rates with CEST MRI.

9. Bioluminescent probes of sulfatase activity.

10. Sulfatase 2 promotes breast cancer progression through regulating some tumor-related factors.

Review 1. Clinical applications of chemical exchange saturation transfer (CEST) MRI.

2. Detecting acid phosphatase enzymatic activity with phenol as a chemical exchange saturation transfer magnetic resonance imaging contrast agent (PhenolCEST MRI).

Review 3. Recent progress in the imaging detection of enzyme activities in vivo.

Review 4. Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

5. Detection of Alkaline Phosphatase Enzyme Activity with a CatalyCEST MRI Biosensor.

Review 6. Probing Reversible Guest Binding with Hyperpolarized ¹²⁹Xe-NMR: Characteristics and Applications for Cucurbit[n]urils.

Review 5. Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility.

Review 1. Clinical applications of chemical exchange saturation transfer (CEST) MRI.

Review 3. Recent progress in the imaging detection of enzyme activities in vivo.

Review 4. Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Review 6. Probing Reversible Guest Binding with Hyperpolarized 129Xe-NMR: Characteristics and Applications for Cucurbit[n]urils.

Review 6. Probing Reversible Guest Binding with Hyperpolarized ¹²⁹Xe-NMR: Characteristics and Applications for Cucurbit[n]urils.