Ayse Kirbas1, Ozgur Kirbas2, Korkut Daglar3, Hasan Ali Inal4, Ozge Kurmus5, Ozgur Kara6, Hakan Timur7, Gulenay Gencosmanoglu8, Nuri Danisman9. 1. Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: drayse1982@yahoo.com. 2. Department of Cardiology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey. Electronic address: ozgurkirbas@yahoo.com. 3. Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: drhkd1@gmail.com. 4. Department of Obstetrics and Gynecology, Konya Education and Research Hospital, Konya, Turkey. Electronic address: dr.hasanaliinal@yahoo.com. 5. Department of Cardiology, Mersin State Hospital, Mersin, Turkey. Electronic address: ozge_kurmus@yahoo.com. 6. Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: drozgurkara@gmail.com. 7. Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: drhakantimur@gmail.com. 8. Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: drgulenay@yahoo.com. 9. Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: nuridanisman@gmail.com.
Abstract
OBJECTIVE: There is increasing evidence that preeclampsia (PE) may also be a risk factor for future cardiovascular diseases (CVDs), including arrhythmia. In this study we aimed to evaluate the association between PE and ventricular repolarization using novel electrocardiogram markers: QT interval duration, Tp-e interval, and Tp-e/QT ratio. MATERIALS AND METHODS: In this controlled cross-sectional study sixty-four pregnant women with PE (31 with mild and 33 with severe disease) and 32 healthy women with uncomplicated pregnancies in the third trimester were compared by measuring QT parameters, Tp-e interval, and Tp-e/QT ratio. RESULTS: Tp-e interval and Tp-e/QT ratio values were significantly higher in both the mild and severe PE groups compared to the healthy pregnant group. CONCLUSION: Prevention of CVD requires that patients be aware of their risk factors, be educated about their risk, and perhaps most importantly perceive them to be at risk. In this study, we documented that PE has a significant effect on ventricular repolarization. This alteration could, in part, explain the increased cardiovascular risk in women with a history of PE. This important association can be used to screen women for increased risk in order to better target counseling regarding lifestyle modifications and to follow up and manage women with a history of hypertensive disease of pregnancy more closely.
OBJECTIVE: There is increasing evidence that preeclampsia (PE) may also be a risk factor for future cardiovascular diseases (CVDs), including arrhythmia. In this study we aimed to evaluate the association between PE and ventricular repolarization using novel electrocardiogram markers: QT interval duration, Tp-e interval, and Tp-e/QT ratio. MATERIALS AND METHODS: In this controlled cross-sectional study sixty-four pregnant women with PE (31 with mild and 33 with severe disease) and 32 healthy women with uncomplicated pregnancies in the third trimester were compared by measuring QT parameters, Tp-e interval, and Tp-e/QT ratio. RESULTS: Tp-e interval and Tp-e/QT ratio values were significantly higher in both the mild and severe PE groups compared to the healthy pregnant group. CONCLUSION: Prevention of CVD requires that patients be aware of their risk factors, be educated about their risk, and perhaps most importantly perceive them to be at risk. In this study, we documented that PE has a significant effect on ventricular repolarization. This alteration could, in part, explain the increased cardiovascular risk in women with a history of PE. This important association can be used to screen women for increased risk in order to better target counseling regarding lifestyle modifications and to follow up and manage women with a history of hypertensive disease of pregnancy more closely.
Authors: Kathleen Bird; Gabriel Chan; Huiqi Lu; Heloise Greeff; John Allen; Derek Abbott; Carlo Menon; Nigel H Lovell; Newton Howard; Wee-Shian Chan; Richard Ribon Fletcher; Aymen Alian; Rabab Ward; Mohamed Elgendi Journal: Front Med (Lausanne) Date: 2020-12-04
Authors: Tomasz Kandzia; Grażyna Markiewicz-Łoskot; Przemysław Binkiewicz Journal: Int J Environ Res Public Health Date: 2022-10-03 Impact factor: 4.614