Ye Xu1, Jiawei Yu2, Tianbo Liu1, Fanling Meng1, Dan Kong1, Ge Lou1. 1. a Department of Gynecology and. 2. b Department of Head and Neck Surgery , Harbin Medical University Cancer Hospital , Harbin , China.
Abstract
OBJECTIVE: To investigate the relationship between F box/WD-40 domain protein 7 (FBXW7) and cervical squamous cancer. METHODS: We investigated the FBXW7 expression in 136 cervical squamous carcinoma cases through immunohistochemistry and Western-blot analysis to evaluate the clinical significance of FBXW7 and to elucidate the relationship of FBXW7 expression with progression-free survival (PFS) and overall survival (OS). RESULTS: Low FBXW7 expression was associated with high histologic grade, lymphovascular space invasion and lymph node metastasis, among other parameters. Patients with low FBXW7 expression exhibited poor OS and PFS. CONCLUSIONS: FBXW7 is related to the susceptibility and prognosis of cervical squamous carcinoma, indicating FBXW7 may be a potentially important target for the prediction of prognosis.
OBJECTIVE: To investigate the relationship between F box/WD-40 domain protein 7 (FBXW7) and cervical squamous cancer. METHODS: We investigated the FBXW7 expression in 136 cervical squamous carcinoma cases through immunohistochemistry and Western-blot analysis to evaluate the clinical significance of FBXW7 and to elucidate the relationship of FBXW7 expression with progression-free survival (PFS) and overall survival (OS). RESULTS: Low FBXW7 expression was associated with high histologic grade, lymphovascular space invasion and lymph node metastasis, among other parameters. Patients with low FBXW7 expression exhibited poor OS and PFS. CONCLUSIONS:FBXW7 is related to the susceptibility and prognosis of cervical squamous carcinoma, indicating FBXW7 may be a potentially important target for the prediction of prognosis.