Antonio D'Agostino1, Lorenzo Trevisiol1, Vittorio Favero2, Michael J Gunson3, Federica Pedica4, Pier Francesco Nocini5, G William Arnett6. 1. Associate Professor, Department of Surgery, Unit of Maxillofacial Surgery and Dentistry, University of Verona, Verona, Italy. 2. Clinical Assistant, Department of Surgery, Unit of Maxillofacial Surgery and Dentistry, University of Verona, Verona, Italy. Electronic address: Vittorio_favero@yahoo.it. 3. Private Practice, Arnett and Gunson Facial Reconstruction, Santa Barbara, CA. 4. Clinical Assistant, Department of Pathology and Diagnostics, University of Verona, Verona, Italy. 5. Professor and Chief, Department of Surgery, Unit of Maxillofacial Surgery and Dentistry, University of Verona, Verona, Italy. 6. Private Practice, Arnett and Gunson Facial Reconstruction, Santa Barbara, CA and Assistant Professor, Department of Oral and Maxillofacial Surgery, Loma Linda University, Loma Linda, CA.
Abstract
PURPOSE: To evaluate the long-term results of cheekbone augmentation using porous hydroxyapatite granules mixed with microfibrillar collagen in a large group of patients. MATERIALS AND METHODS: Four hundred thirty patients who underwent zygomatic augmentation and intermaxillary osteotomy were evaluated clinically, radiologically, and histologically. RESULTS: Complications were found in 13 patients (1.56%). There were no relevant radiologic differences in prosthesis volume after 1 month (T1) or after 24 months (T2) in any patient; there were no clinically relevant differences in 110 patients after 36 months. At T1, the prosthesis had a granular structure and the granules had not migrated; at T2, the prosthesis was staunchly adhering to the underlying bone. Over time, the radiopacity of the material increased. Histologic results of 19 biopsy specimens obtained from 8 patients 2 years after the procedure showed prominent ossification with low inflammation, confirming new bone formation over time. According to the visual analog scale, the patients were generally satisfied with the aspects that were considered. CONCLUSION: Hydroxyapatite and collagen composite used during malarplasty produced a successful outcome. Its main drawback is a learning curve that is longer than for more frequently used implantable biomaterials.
PURPOSE: To evaluate the long-term results of cheekbone augmentation using porous hydroxyapatite granules mixed with microfibrillar collagen in a large group of patients. MATERIALS AND METHODS: Four hundred thirty patients who underwent zygomatic augmentation and intermaxillary osteotomy were evaluated clinically, radiologically, and histologically. RESULTS: Complications were found in 13 patients (1.56%). There were no relevant radiologic differences in prosthesis volume after 1 month (T1) or after 24 months (T2) in any patient; there were no clinically relevant differences in 110 patients after 36 months. At T1, the prosthesis had a granular structure and the granules had not migrated; at T2, the prosthesis was staunchly adhering to the underlying bone. Over time, the radiopacity of the material increased. Histologic results of 19 biopsy specimens obtained from 8 patients 2 years after the procedure showed prominent ossification with low inflammation, confirming new bone formation over time. According to the visual analog scale, the patients were generally satisfied with the aspects that were considered. CONCLUSION:Hydroxyapatite and collagen composite used during malarplasty produced a successful outcome. Its main drawback is a learning curve that is longer than for more frequently used implantable biomaterials.
Authors: Maria Rosa Iaquinta; Elisa Mazzoni; Marco Manfrini; Antonio D'Agostino; Lorenzo Trevisiol; Riccardo Nocini; Leonardo Trombelli; Giovanni Barbanti-Brodano; Fernanda Martini; Mauro Tognon Journal: Int J Mol Sci Date: 2019-01-31 Impact factor: 5.923
Authors: Maria Rosa Iaquinta; Fernanda Martini; Antonio D'Agostino; Lorenzo Trevisiol; Massimo Bersani; Elena Torreggiani; Mauro Tognon; John Charles Rotondo; Elisa Mazzoni Journal: Front Bioeng Biotechnol Date: 2022-06-27
Authors: Elisa Mazzoni; Antonio D'Agostino; Maria Rosa Iaquinta; Ilaria Bononi; Lorenzo Trevisiol; John Charles Rotondo; Simone Patergnani; Carlotta Giorgi; Michael J Gunson; G William Arnett; Pier Francesco Nocini; Mauro Tognon; Fernanda Martini Journal: Stem Cells Transl Med Date: 2019-12-13 Impact factor: 6.940
Authors: Maria Rosa Iaquinta; Elisa Mazzoni; Ilaria Bononi; John Charles Rotondo; Chiara Mazziotta; Monica Montesi; Simone Sprio; Anna Tampieri; Mauro Tognon; Fernanda Martini Journal: Front Cell Dev Biol Date: 2019-11-12