Melanie Drolet1, Shelley L Deeks2, Erich Kliewer3, Grace Musto4, Pascal Lambert4, Marc Brisson5. 1. Centre de recherche du CHU de Québec, Axe SP-POS, Québec, Canada; Département de médecine sociale et préventive, Université Laval, Québec, Canada. 2. Public Health Ontario, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. 3. CancerCare Manitoba, Manitoba, Canada; University of Manitoba, Manitoba, Canada; British Columbia Cancer Agency, British Columbia, Canada. 4. CancerCare Manitoba, Manitoba, Canada. 5. Centre de recherche du CHU de Québec, Axe SP-POS, Québec, Canada; Département de médecine sociale et préventive, Université Laval, Québec, Canada; Department of Infectious Disease Epidemiology, Imperial College, London, UK. Electronic address: Marc.Brisson@crchudequebec.ulaval.ca.
Abstract
BACKGROUND: Human papillomavirus (HPV) vaccination programs have been implemented in more than 50 countries. These programs offer tremendous promise of reducing HPV-related disease burden. However, failure to achieve high coverage among high-risk groups may mitigate program success and increase inequalities. We examined sociodemographic inequalities in HPV vaccination coverage in 4 Canadian provinces (Quebec (QC), Ontario (ON), Manitoba (MB), British Columbia (BC)). METHODS: We obtained annual HPV vaccination coverage of pre-adolescent girls at provincial and regional levels, from the start of programs to 2012/2013. Regions refer to administrative areas responsible for vaccine implementation and monitoring (there are 18/36/10/16 regions in QC/ON/MB/BC). We obtained regions' sociodemographic characteristics from Statistics Canada Census. We used univariate weighted linear regression to examine the associations between regions' sociodemographic characteristics and HPV vaccination coverage. RESULTS: Provincial HPV vaccination coverage is generally high (QC:78%; ON:80%; MB:64%, BC:69%, 2012/13). QC had the highest provincial vaccination coverage since the program start, but had the greatest inequalities. In QC, regional HPV vaccination coverage was lower in regions with higher proportions of socially deprived individuals, immigrants, and/or native English speakers (p<0.0001). These inequalities remained stable over time. Regional-level analysis did not reveal inequalities in ON, MB and BC. CONCLUSION: School-based HPV vaccination programs have resulted in high vaccination coverage in four Canadian provinces. Nonetheless, high overall coverage did not necessarily translate into equality in coverage. Future work is needed to understand underlying causes of inequalities and how this could impact existing inequalities in HPV-related diseases and overall program success.
BACKGROUND:Human papillomavirus (HPV) vaccination programs have been implemented in more than 50 countries. These programs offer tremendous promise of reducing HPV-related disease burden. However, failure to achieve high coverage among high-risk groups may mitigate program success and increase inequalities. We examined sociodemographic inequalities in HPV vaccination coverage in 4 Canadian provinces (Quebec (QC), Ontario (ON), Manitoba (MB), British Columbia (BC)). METHODS: We obtained annual HPV vaccination coverage of pre-adolescent girls at provincial and regional levels, from the start of programs to 2012/2013. Regions refer to administrative areas responsible for vaccine implementation and monitoring (there are 18/36/10/16 regions in QC/ON/MB/BC). We obtained regions' sociodemographic characteristics from Statistics Canada Census. We used univariate weighted linear regression to examine the associations between regions' sociodemographic characteristics and HPV vaccination coverage. RESULTS: Provincial HPV vaccination coverage is generally high (QC:78%; ON:80%; MB:64%, BC:69%, 2012/13). QC had the highest provincial vaccination coverage since the program start, but had the greatest inequalities. In QC, regional HPV vaccination coverage was lower in regions with higher proportions of socially deprived individuals, immigrants, and/or native English speakers (p<0.0001). These inequalities remained stable over time. Regional-level analysis did not reveal inequalities in ON, MB and BC. CONCLUSION: School-based HPV vaccination programs have resulted in high vaccination coverage in four Canadian provinces. Nonetheless, high overall coverage did not necessarily translate into equality in coverage. Future work is needed to understand underlying causes of inequalities and how this could impact existing inequalities in HPV-related diseases and overall program success.
Authors: Steven Habbous; Karen P Chu; Harold Lau; Melissa Schorr; Mathieos Belayneh; Michael N Ha; Scott Murray; Brian O'Sullivan; Shao Hui Huang; Stephanie Snow; Matthew Parliament; Desiree Hao; Winson Y Cheung; Wei Xu; Geoffrey Liu Journal: CMAJ Date: 2017-08-14 Impact factor: 8.262
Authors: Francesco Venturelli; Flavia Baldacchini; Cinzia Campari; Cinzia Perilli; Maria Grazia Pascucci; Alba Carola Finarelli; Luigi Moscara; Paolo Giorgi Rossi Journal: BMJ Open Date: 2017-09-25 Impact factor: 2.692