AIMS: To report a case detailing the early histopathogenesis of Burkitt lymphoma (BL), Epstein-Barr virus (EBV) positive, in the clinical setting of HIV infection. METHODS AND RESULTS: We describe a 57 year-old woman with newly diagnosed HIV infection who presented with unilateral localized axillary lymphadenopathy. Histopathological, immunohistochemical, and flow cytometric analyses were performed and showed EBV-positive nests of Burkitt cells, including rare nests also positive for cytomegalovirus, exclusively located within hyperplastic monocytoid B-cell areas of HIV lymphadenitis. Due to positron emission tomography/computed tomography findings of persistent localized lymphadenopathy with markedly increased fludeoxyglucose avidity a core needle biopsy was performed. Histopathological, immunohistochemical, fluorescence in situ hybridization, and flow cytometric analyses confirmed BL. CONCLUSIONS: Early histopathogenesis of HIV-associated BL occurred as nests of EBV-positive Burkitt cells within prominent monocytoid B-cell areas in our case. The results equip the pathologist to identify a very subtle Burkitt microlymphoma which would allow for prompt and appropriate chemotherapeutic intervention and may promote research into the possible relationship between monocytoid B cells and BL.
AIMS: To report a case detailing the early histopathogenesis of Burkitt lymphoma (BL), Epstein-Barr virus (EBV) positive, in the clinical setting of HIV infection. METHODS AND RESULTS: We describe a 57 year-old woman with newly diagnosed HIV infection who presented with unilateral localized axillary lymphadenopathy. Histopathological, immunohistochemical, and flow cytometric analyses were performed and showed EBV-positive nests of Burkitt cells, including rare nests also positive for cytomegalovirus, exclusively located within hyperplastic monocytoid B-cell areas of HIV lymphadenitis. Due to positron emission tomography/computed tomography findings of persistent localized lymphadenopathy with markedly increased fludeoxyglucose avidity a core needle biopsy was performed. Histopathological, immunohistochemical, fluorescence in situ hybridization, and flow cytometric analyses confirmed BL. CONCLUSIONS: Early histopathogenesis of HIV-associated BL occurred as nests of EBV-positive Burkitt cells within prominent monocytoid B-cell areas in our case. The results equip the pathologist to identify a very subtle Burkitt microlymphoma which would allow for prompt and appropriate chemotherapeutic intervention and may promote research into the possible relationship between monocytoid B cells and BL.
Authors: M Q Du; H Liu; T C Diss; H Ye; R A Hamoudi; N Dupin; V Meignin; E Oksenhendler; C Boshoff; P G Isaacson Journal: Blood Date: 2001-04-01 Impact factor: 22.113
Authors: N Dupin; T L Diss; P Kellam; M Tulliez; M Q Du; D Sicard; R A Weiss; P G Isaacson; C Boshoff Journal: Blood Date: 2000-02-15 Impact factor: 22.113
Authors: Eric Oksenhendler; Emmanuelle Boulanger; Lionel Galicier; Ming-Qing Du; Nicolas Dupin; Tim C Diss; Rifat Hamoudi; Marie-Thérèse Daniel; Félix Agbalika; Chris Boshoff; Jean-Pierre Clauvel; Peter G Isaacson; Véronique Meignin Journal: Blood Date: 2002-04-01 Impact factor: 22.113
Authors: J L Ziegler; W L Drew; R C Miner; L Mintz; E Rosenbaum; J Gershow; E T Lennette; J Greenspan; E Shillitoe; J Beckstead; C Casavant; K Yamamoto Journal: Lancet Date: 1982-09-18 Impact factor: 79.321