Literature DB >> 26953516

Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery.

Hyung Woo Choi1, Jihoon Kim1, Jinhwan Kim2, Yonghwi Kim1, Hyun Beom Song3, Jeong Hun Kim3, Kimoon Kim1,2, Won Jong Kim1,2.   

Abstract

We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid generation are used as triggers for uncapping the gatekeeper and releasing NO. The acids generated from a light-activated pH-jump agent loaded in the mesoporous nanoparticles accelerated the degradation of the CaP-coating layers on the nanoparticles, facilitating the light-responsive NO release from diazeniumdiolate by exposing a NO donor to physiological conditions. Using the combination of the pH-jump reagent and CaP coating, we successfully developed a light-responsive gatekeeper system for spatiotemporal-controlled NO delivery.

Entities:  

Keywords:  calcium phosphate; corneal wound healing; gatekeeper; nitric oxide delivery; pH-jump reagent

Year:  2016        PMID： 26953516     DOI： 10.1021/acsnano.5b07483

Source DB:  PubMed          Journal:  ACS Nano        ISSN： 1936-0851            Impact factor:   15.881


  10 in total

Review 1.  Combination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapy.

Authors:  Jihoon Kim; Bryant C Yung; Won Jong Kim; Xiaoyuan Chen
Journal:  J Control Release       Date:  2016-12-26       Impact factor: 9.776

2.  The fourth annual BRDS on genome editing and silencing for precision medicines.

Authors:  Amit Kumar Chaudhary; Rajan Sharma Bhattarai; Ram I Mahato
Journal:  Drug Deliv Transl Res       Date:  2018-02       Impact factor: 4.617

3.  Design, Synthesis, and Antibacterial Activity of a Multivalent Polycationic Calix[4]arene-NO Photodonor Conjugate.

Authors:  Grazia M L Consoli; Ivana Di Bari; Anna R Blanco; Antonia Nostro; Manuela D'Arrigo; Venerando Pistarà; Salvatore Sortino
Journal:  ACS Med Chem Lett       Date:  2017-07-05       Impact factor: 4.345

4.  Light: A Magical Tool for Controlled Drug Delivery.

Authors:  Yu Tao; Hon Fai Chan; Bingyang Shi; Mingqiang Li; Kam W Leong
Journal:  Adv Funct Mater       Date:  2020-09-09       Impact factor: 18.808

Review 5.  Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy.

Authors:  Jihoon Kim; Susan N Thomas
Journal:  Pharmacol Rev       Date:  2022-10       Impact factor: 18.923

Review 6.  Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications.

Authors:  Suzana Hamdan; Irena Pastar; Stefan Drakulich; Emre Dikici; Marjana Tomic-Canic; Sapna Deo; Sylvia Daunert
Journal:  ACS Cent Sci       Date:  2017-02-27       Impact factor: 14.553

7.  Quantitative Modeling Extends the Antibacterial Activity of Nitric Oxide.

Authors:  Darshan M Sivaloganathan; Mark P Brynildsen
Journal:  Front Physiol       Date:  2020-04-17       Impact factor: 4.566

Review 8.  Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy.

Authors:  Tianxiang Ma; Zhexi Zhang; Yu Chen; Haoran Su; Xiaoyan Deng; Xiao Liu; Yubo Fan
Journal:  Int J Mol Sci       Date:  2021-11-10       Impact factor: 5.923

9.  Chloromethyl-modified Ru(ii) complexes enabling large pH jumps at low concentrations through photoinduced hydrolysis.

Authors:  Na Tian; Weize Sun; Yang Feng; Xusheng Guo; Jian Lu; Chao Li; Yuanjun Hou; Xuesong Wang; Qianxiong Zhou
Journal:  Chem Sci       Date:  2019-10-24       Impact factor: 9.825

10.  Light-triggered nitric oxide (NO) release from photoresponsive polymersomes for corneal wound healing.

Authors:  Yutian Duan; Yong Wang; Xiaohu Li; Guozhen Zhang; Guoying Zhang; Jinming Hu
Journal:  Chem Sci       Date:  2019-11-05       Impact factor: 9.825
  10 in total

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