Literature DB >> 2695340

Guinea-pig tracheal epithelium and endothelin.

D W Hay1.   

Abstract

Removal of the epithelium increased the responsiveness of isolated guinea-pig trachea to the contractile effects of endothelin. This phenomenon was observed in the presence of indomethacin (5 microM), captopril (10 microM), bacitracin (20 micrograms/ml) or leupeptin (50 microM), but was inhibited by phosphoramidon (10 microM). Bacitrain enhanced contraction produced by endothelin. The increased responsiveness of denuded guinea-pig trachea to endothelin may be due to removal of an epithelium-derived phosphoramidon-sensitive peptidase.

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Year:  1989        PMID： 2695340     DOI： 10.1016/0014-2999(89)90114-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  Mechanism of endothelin-induced contraction in guinea-pig trachea: comparison with rat aorta.

Authors:  D W Hay
Journal:  Br J Pharmacol       Date:  1990-06       Impact factor: 8.739

2.  Comparison of the effects of intra-arterial and aerosol administration of endothelin-1 (ET-1) in the guinea-pig isolated lung.

Authors:  F Pons; C Touvay; V Lagente; J M Mencia-Huerta; P Braquet
Journal:  Br J Pharmacol       Date:  1991-04       Impact factor: 8.739

3.  Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea.

Authors:  D W Hay; W C Hubbard; B J Undem
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

4.  Role of the neutral endopeptidase 24.11 in the conversion of big endothelins in guinea-pig lung parenchyma.

Authors:  N Lebel; P D'Orléans-Juste; A Fournier; P Sirois
Journal:  Br J Pharmacol       Date:  1996-01       Impact factor: 8.739

5.  Endothelin-induced contraction and mediator release in human bronchus.

Authors:  D W Hay; W C Hubbard; B J Undem
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739

6.  Contractile activity of big endothelin-1 on the human isolated bronchus.

Authors:  C Advenier; V Lagente; Y Zhang; E Naline
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739

7.  Phosphoramidon potentiates the contractile response to endothelin-3, but not endothelin-1 in isolated airway tissue.

Authors:  K O McKay; J L Black; C L Armour
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

8.  Induction by endothelin-1 of epithelium-dependent relaxation of guinea-pig trachea in vitro: role for nitric oxide.

Authors:  J G Filep; B Battistini; P Sirois
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

9.  Characterization of ETB receptors mediating contractions induced by endothelin-1 or IRL 1620 in guinea-pig isolated airways: effects of BQ-123, FR139317 or PD 145065.

Authors:  B Battistini; T D Warner; A Fournier; J R Vane
Journal:  Br J Pharmacol       Date:  1994-04       Impact factor: 8.739
  9 in total

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