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Literature DB >> 26953326

Serial Dissection of Parasite Gene Families.

Abstract

Calcium ion signaling regulates central aspects of the biology controlling stage and life cycle transitions of apicomplexan parasites. In the current issue of Infection and Immunity, Long and coworkers (S. Long, Q. Wang, and L. D. Sibley, Infect Immun 84:1262-1273, 2016, http://dx.doi.org/10.1128/IAI.01173-15) describe a powerful genetic system enabling reliable serial genetic dissection of a large gene family encoding novel calcium-dependent protein kinases (CDPKs) that provides new insights into the roles of CDPKs during Toxoplasma gondii infection.

Entities: Chemical Disease

Mesh：

Year: 2016 PMID： 26953326 PMCID： PMC4862726 DOI： 10.1128/IAI.00175-16

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

36 in total

1. Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining.

Authors: Barbara A Fox; Jessica G Ristuccia; Jason P Gigley; David J Bzik
Journal: Eukaryot Cell Date: 2009-02-13

2. Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80.

Authors: My-Hang Huynh; Vern B Carruthers
Journal: Eukaryot Cell Date: 2009-02-13

Review 3. Designing selective inhibitors for calcium-dependent protein kinases in apicomplexans.

Authors: Raymond Hui; Majida El Bakkouri; L David Sibley
Journal: Trends Pharmacol Sci Date: 2015-05-20 Impact factor: 14.819

4. Assessment of phosphorylation in Toxoplasma glideosome assembly and function.

Authors: Damien Jacot; Karine Frénal; Jean-Baptiste Marq; Pushkar Sharma; Dominique Soldati-Favre
Journal: Cell Microbiol Date: 2014-05-23 Impact factor: 3.715

5. Calcium entry in Toxoplasma gondii and its enhancing effect of invasion-linked traits.

Authors: Douglas A Pace; Ciara A McKnight; Jing Liu; Veronica Jimenez; Silvia N J Moreno
Journal: J Biol Chem Date: 2014-05-27 Impact factor: 5.157

6. Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria.

Authors: R G Donald; D S Roos
Journal: Proc Natl Acad Sci U S A Date: 1993-12-15 Impact factor: 11.205

7. Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii.

Authors: Ryan C Murphy; Kayode K Ojo; Eric T Larson; Alejandro Castellanos-Gonzalez; B Gayani K Perera; Katelyn R Keyloun; Jessica E Kim; Janhavi G Bhandari; Natascha R Muller; Christophe L M J Verlinde; A Clinton White; Ethan A Merritt; Wesley C Van Voorhis; Dustin J Maly
Journal: ACS Med Chem Lett Date: 2010-10-14 Impact factor: 4.345

8. Type II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection.

Authors: Barbara A Fox; Alejandra Falla; Leah M Rommereim; Tadakimi Tomita; Jason P Gigley; Corinne Mercier; Marie-France Cesbron-Delauw; Louis M Weiss; David J Bzik
Journal: Eukaryot Cell Date: 2011-04-29

9. Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.

Authors: Steven M Johnson; Ryan C Murphy; Jennifer A Geiger; Amy E DeRocher; Zhongsheng Zhang; Kayode K Ojo; Eric T Larson; B Gayani K Perera; Edward J Dale; Panqing He; Molly C Reid; Anna M W Fox; Natascha R Mueller; Ethan A Merritt; Erkang Fan; Marilyn Parsons; Wesley C Van Voorhis; Dustin J Maly
Journal: J Med Chem Date: 2012-02-27 Impact factor: 7.446

10. Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii.

Authors: Sebastian Lourido; Chao Zhang; Michael S Lopez; Keliang Tang; Jennifer Barks; Qiuling Wang; Scott A Wildman; Kevan M Shokat; L David Sibley
Journal: J Med Chem Date: 2013-03-26 Impact factor: 7.446

1 in total

1. The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection.

Authors: Barbara A Fox; Leah M Rommereim; Rebekah B Guevara; Alejandra Falla; Miryam Andrea Hortua Triana; Yanbo Sun; David J Bzik
Journal: mBio Date: 2016-05-10 Impact factor: 7.867

1 in total