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Literature DB >> 2695328

Comparative in vitro antibacterial activity of the new carbapenem meropenem (SM-7338).

M R Visser¹, I M Hoepelman, H Beumer, M Rozenberg-Arska, J Verhoef.

Abstract

The in vitro antimicrobial activity of the new carbapenem meropenem (SM-7338) was determined by an agar dilution method in comparison with imipenem, ticarcillin/calvulanic acid, ceftazidime and the fourth-generation cephalosporin cefepime (BMY 28142). Meropenem showed superior activity against Enterobacteriaceae (MIC90 less than or equal to 0.06 mg/l) and against non-fermentative gram-negative rods, with the exception of Xanthomonas maltophilia. Meropenem had excellent activity against beta-lactamase-producing Haemophilus influenzae and Neisseria gonorrhoeae, and against the Bacteroides fragilis group. Imipenem was slightly more active then meropenem against gram-positive cocci especially Enterococcus faecalis.

Entities: Chemical Species

Mesh：

Substances：

Year: 1989 PMID： 2695328 DOI： 10.1007/BF01975170

Source DB: PubMed Journal: Eur J Clin Microbiol Infect Dis ISSN： 0934-9723 Impact factor: 3.267

4 in total

1. Multicenter in vitro evaluation of SM-7338, a new carbapenem.

Authors: R N Jones; K E Aldridge; S D Allen; A L Barry; P C Fuchs; E H Gerlach; M A Pfaller
Journal: Antimicrob Agents Chemother Date: 1989-04 Impact factor: 5.191

2. In vitro activity and beta-lactamase stability of a new carbapenem, SM-7338.

Authors: H C Neu; A Novelli; N X Chin
Journal: Antimicrob Agents Chemother Date: 1989-07 Impact factor: 5.191

3. Antibiotic sensitivity testing. Report of an international collaborative study.

Authors: H M Ericsson; J C Sherris
Journal: Acta Pathol Microbiol Scand B Microbiol Immunol Date: 1971

4. In vitro antibacterial activity of SM-7338, a carbapenem antibiotic with stability to dehydropeptidase I.

Authors: J R Edwards; P J Turner; C Wannop; E S Withnell; A J Grindey; K Nairn
Journal: Antimicrob Agents Chemother Date: 1989-02 Impact factor: 5.191

4 in total

6 in total

1. Comparative in vitro pharmacodynamics of imipenem and meropenem against Pseudomonas aeruginosa.

Authors: R White; L Friedrich; D Burgess; D Warkentin; J Bosso
Journal: Antimicrob Agents Chemother Date: 1996-04 Impact factor: 5.191

Review 2. Cefepime clinical pharmacokinetics.

Authors: M P Okamoto; R K Nakahiro; A Chin; A Bedikian
Journal: Clin Pharmacokinet Date: 1993-08 Impact factor: 6.447

Comparative in vitro antibacterial activity of the new carbapenem meropenem (SM-7338).

1. Multicenter in vitro evaluation of SM-7338, a new carbapenem.

2. In vitro activity and beta-lactamase stability of a new carbapenem, SM-7338.

3. Antibiotic sensitivity testing. Report of an international collaborative study.

4. In vitro antibacterial activity of SM-7338, a carbapenem antibiotic with stability to dehydropeptidase I.

1. Comparative in vitro pharmacodynamics of imipenem and meropenem against Pseudomonas aeruginosa.

Review 2. Cefepime clinical pharmacokinetics.

3. Pharmacokinetics of cefepime in patients with respiratory tract infections.

Review 4. Meropenem. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy.

Review 5. Cefepime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

6. Gonococcal subcutaneous abscess and pyomyositis: a case report.