Guo-Ming Zhang1, Yong-Jie Xia2. 1. Department of Laboratory, Shuyang People's Hospital, Shuyang, China. zly52120@163.com. 2. School of Public Health, Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China.
Abstract
BACKGROUND: The establishment of reference intervals of total bilirubin, Alanine aminotransferase (ALT), aspartate aminotransferases (AST), and creatinine provided necessary reference in screening and diagnosis of various kidney and liver diseases. However, these reference intervals were not available to estimate liver fibrosis degree. The purpose of this study is to establish the reference intervals of fibrosis index based on the four indicators (FIB-4) in apparently healthy elderly Chinese. METHODS: A total of 24,949 blood specimens were collected by the standard procedures, and ALT, AST, and PLT were determined. FIB-4 were calculated by the following formula: FIB-4 = (age [years] × AST [U/l])/((PLT [10(9) /l]) × (ALT [U/l])(1/2) ).The elderly's FIB-4 were analyzed between the same age of different sexes and different ages of the same sex. Statistical data were analyzed by SPSS18.0 software. RESULTS: Reference intervals of FIB-4 index, established for the healthy elderly, were 0.9923-4.5424 for males and 0.9007-4.1934 for females. CONCLUSION: We established reference intervals of FIB-4 index. This research provided reference value that can be used by relevant clinicians and inspection officers.
BACKGROUND: The establishment of reference intervals of total bilirubin, Alanine aminotransferase (ALT), aspartate aminotransferases (AST), and creatinine provided necessary reference in screening and diagnosis of various kidney and liver diseases. However, these reference intervals were not available to estimate liver fibrosis degree. The purpose of this study is to establish the reference intervals of fibrosis index based on the four indicators (FIB-4) in apparently healthy elderly Chinese. METHODS: A total of 24,949 blood specimens were collected by the standard procedures, and ALT, AST, and PLT were determined. FIB-4 were calculated by the following formula: FIB-4 = (age [years] × AST [U/l])/((PLT [10(9) /l]) × (ALT [U/l])(1/2) ).The elderly's FIB-4 were analyzed between the same age of different sexes and different ages of the same sex. Statistical data were analyzed by SPSS18.0 software. RESULTS: Reference intervals of FIB-4 index, established for the healthy elderly, were 0.9923-4.5424 for males and 0.9007-4.1934 for females. CONCLUSION: We established reference intervals of FIB-4 index. This research provided reference value that can be used by relevant clinicians and inspection officers.
Authors: Dirk P Boer; Yolanda B de Rijke; Wim C Hop; Karlien Cransberg; Eiske M Dorresteijn Journal: Pediatr Nephrol Date: 2010-05-27 Impact factor: 3.714
Authors: Leon A Adams; Max Bulsara; Enrico Rossi; Bastiaan DeBoer; David Speers; Jacob George; James Kench; Geoffrey Farrell; Geoffrey W McCaughan; Gary P Jeffrey Journal: Clin Chem Date: 2005-07-28 Impact factor: 8.327