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Literature DB >> 26953210

Clarithromycin Resistance Mechanisms of Epidemic β-Lactamase-Nonproducing Ampicillin-Resistant Haemophilus influenzae Strains in Japan.

Shoji Seyama¹, Takeaki Wajima¹, Hidemasa Nakaminami¹, Norihisa Noguchi².

Abstract

The aim of this study was to clarify the clarithromycin resistance mechanisms of β-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae strains. In all clarithromycin-resistant strains, the transcript level of acrB was significantly elevated, and these strains had a frameshift mutation in acrR Introduction of the acrR mutation into H. influenzae Rd generated a clarithromycin-resistant transformant with the same MIC as the donor strain. Our results indicate that the acrR mutation confers clarithromycin resistance by the increasing the transcription of acrB.

Entities: Chemical Gene Species

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Year: 2016 PMID： 26953210 PMCID： PMC4862528 DOI： 10.1128/AAC.00163-16

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

20 in total

1. Genetic and molecular characterization of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae with unusually high resistance to ampicillin.

Authors: Frank S Kaczmarek; Thomas D Gootz; Fadia Dib-Hajj; Wenchi Shang; Shawn Hallowell; Melissa Cronan
Journal: Antimicrob Agents Chemother Date: 2004-05 Impact factor: 5.191

2. A report from the committee on microbroth dilution antimicrobial susceptibility testing : issues in antimicrobial susceptibility testing of Haemophilus influenzae: a comparison of the Japanese Society of Chemotherapy lysed horse blood and the CLSI HTM broth microdilution methods.

Authors: Keizo Yamaguchi; Yoichi Hirakata; Intetsu Kobayashi; Masanari Ikedo; Akira Ohno
Journal: J Infect Chemother Date: 2011-09-06 Impact factor: 2.211

3. Acquired macrolide resistance genes in Haemophilus influenzae?

Authors: Christopher T Atkinson; Dale A Kunde; Stephen G Tristram
Journal: J Antimicrob Chemother Date: 2015-04-20 Impact factor: 5.790

4. Antimicrobial susceptibilities and distribution of resistance genes for beta-lactams and macrolides in Streptococcus pneumoniae isolated between 2002 and 2004 in Tokyo.

Authors: Norihisa Noguchi; Junko Tano; Yutaka Nasu; Masaharu Koyama; Koji Narui; Hajime Kamishima; Tetsuya Saito; Kazumitsu Tsuyuki; Masanori Sasatsu
Journal: Int J Antimicrob Agents Date: 2007-01 Impact factor: 5.283

5. The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump.

Authors: L Sánchez; W Pan; M Viñas; H Nikaido
Journal: J Bacteriol Date: 1997-11 Impact factor: 3.490

6. Characterization of macrolide resistance genes in Haemophilus influenzae isolated from children with cystic fibrosis.

Authors: Marilyn C Roberts; Olusegun O Soge; David B No
Journal: J Antimicrob Chemother Date: 2010-11-16 Impact factor: 5.790

7. Investigations of Mycoplasma pneumoniae infections in the United States: trends in molecular typing and macrolide resistance from 2006 to 2013.

Authors: Maureen H Diaz; Alvaro J Benitez; Jonas M Winchell
Journal: J Clin Microbiol Date: 2014-10-29 Impact factor: 5.948

8. Effects of an efflux mechanism and ribosomal mutations on macrolide susceptibility of Haemophilus influenzae clinical isolates.

Authors: Mihaela Peric; Bülent Bozdogan; Michael R Jacobs; Peter C Appelbaum
Journal: Antimicrob Agents Chemother Date: 2003-03 Impact factor: 5.191

9. Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus.

Authors: Hidemasa Nakaminami; Norihisa Noguchi; Masanori Sasatsu
Journal: Antimicrob Agents Chemother Date: 2010-07-26 Impact factor: 5.191

10. The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals.

Authors: D Ma; M Alberti; C Lynch; H Nikaido; J E Hearst
Journal: Mol Microbiol Date: 1996-01 Impact factor: 3.501

8 in total

1. Amino Acid Substitution in the Major Multidrug Efflux Transporter Protein AcrB Contributes to Low Susceptibility to Azithromycin in Haemophilus influenzae.

Authors: Shoji Seyama; Takeaki Wajima; Hidemasa Nakaminami; Norihisa Noguchi
Journal: Antimicrob Agents Chemother Date: 2017-10-24 Impact factor: 5.191

2. Carbapenem-Nonsusceptible Haemophilus influenzae with Penicillin-Binding Protein 3 Containing an Amino Acid Insertion.

Authors: Kazuki Kitaoka; Kouji Kimura; Hiromitsu Kitanaka; Hirotsugu Banno; Wanchun Jin; Jun-Ichi Wachino; Yoshichika Arakawa
Journal: Antimicrob Agents Chemother Date: 2018-07-27 Impact factor: 5.191

3. Evidence of mutations conferring resistance to clarithromycin in wastewater and activated sludge.

Authors: Anna Gnida; Ewa Felis; Aleksandra Ziembińska-Buczyńska; Aneta Łuczkiewicz; Joanna Surmacz-Górska; Krystyna Olańczuk-Neyman
Journal: 3 Biotech Date: 2019-11-29 Impact factor: 2.406

4. Oldenlandia diffusa Extract Inhibits Biofilm Formation by Haemophilus influenzae Clinical Isolates.

Authors: Takeaki Wajima; Yui Anzai; Tetsuya Yamada; Hideaki Ikoshi; Norihisa Noguchi
Journal: PLoS One Date: 2016-11-30 Impact factor: 3.240

5. Single nucleotide polymorphisms in genes encoding penicillin-binding proteins in β-lactamase-negative ampicillin-resistant Haemophilus influenzae in Japan.

Authors: Kazuhisa Misawa; Norihito Tarumoto; Shinsuke Tamura; Morichika Osa; Takaaki Hamamoto; Atsushi Yuki; Yuji Kouzaki; Kazuo Imai; Runtuwene Lucky Ronald; Toshiyuki Yamaguchi; Takashi Murakami; Shigefumi Maesaki; Yutaka Suzuki; Akihiko Kawana; Takuya Maeda
Journal: BMC Res Notes Date: 2018-01-20