Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A CRISPR Approach for Reactivating Latent HIV-1.

Literature DB >> 26952919

A CRISPR Approach for Reactivating Latent HIV-1.

Angel Lin¹, Zachary Klase¹.

Abstract

Entities: Species

Year: 2016 PMID： 26952919 PMCID： PMC4786933 DOI： 10.1038/mt.2016.30

Source DB: PubMed Journal: Mol Ther ISSN： 1525-0016 Impact factor: 11.454

Keyword Cloud
References

× No keyword cloud information.

16 in total

1. Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter.

Authors: Haiyan Ji; Zhengtao Jiang; Panpan Lu; Li Ma; Chuan Li; Hanyu Pan; Zheng Fu; Xiying Qu; Pengfei Wang; Junxiao Deng; Xinyi Yang; Jianhua Wang; Huanzhang Zhu
Journal: Mol Ther Date: 2016-01-18 Impact factor: 11.454

2. RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection.

Authors: Wenhui Hu; Rafal Kaminski; Fan Yang; Yonggang Zhang; Laura Cosentino; Fang Li; Biao Luo; David Alvarez-Carbonell; Yoelvis Garcia-Mesa; Jonathan Karn; Xianming Mo; Kamel Khalili
Journal: Proc Natl Acad Sci U S A Date: 2014-07-21 Impact factor: 11.205

3. HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat.

Authors: Nancy M Archin; Rosalie Bateson; Manoj K Tripathy; Amanda M Crooks; Kuo-Hsiung Yang; Noelle P Dahl; Mary F Kearney; Elizabeth M Anderson; John M Coffin; Matthew C Strain; Douglas D Richman; Kevin R Robertson; Angela D Kashuba; Ronald J Bosch; Daria J Hazuda; Joann D Kuruc; Joseph J Eron; David M Margolis
Journal: J Infect Dis Date: 2014-03-11 Impact factor: 5.226

Review 4. Targeting HIV latency: pharmacologic strategies toward eradication.

Authors: Sifei Xing; Robert F Siliciano
Journal: Drug Discov Today Date: 2012-12-25 Impact factor: 7.851

Review 5. The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit.

Authors: Jonathan Karn
Journal: Curr Opin HIV AIDS Date: 2011-01 Impact factor: 4.283

6. Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction.

Authors: Mudit Tyagi; Richard John Pearson; Jonathan Karn
Journal: J Virol Date: 2010-04-21 Impact factor: 5.103

A CRISPR Approach for Reactivating Latent HIV-1.

1. Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter.

2. RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection.

3. HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat.

Review 4. Targeting HIV latency: pharmacologic strategies toward eradication.

Review 5. The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit.

6. Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction.

7. Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy.

8. Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection.

Review 9. An integrated overview of HIV-1 latency.

Review 10. Cellular and molecular mechanisms involved in the establishment of HIV-1 latency.