Literature DB >> 26952905

Encapsulation of cannabinoid drugs in nanostructured lipid carriers.

Elisabetta Esposito1, Markus Drechsler2, Rita Cortesi1, Claudio Nastruzzi3.   

Abstract

This study describes the development and optimization of a method to encapsulate the potent and expensive cannabinoids drugs in nanostructured lipid carriers; namely, URB597, AM251 and rimonabant have been considered. NLC production by melt and ultrasonication protocol has been specifically designed to optimize nanoparticle recovery and drug encapsulation efficiency. Special care has been devoted to the modality of oil and water phase emulsification and the entire production has been studied and discussed. NLC recovery, morphology, dimensional distribution and encapsulation efficiency are presented.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cannabinoid drugs; Cryo-TEM; Nanostructured lipid carriers

Mesh：

Substances：

Year:  2016        PMID： 26952905     DOI： 10.1016/j.ejpb.2016.03.005

Source DB:  PubMed          Journal:  Eur J Pharm Biopharm        ISSN： 0939-6411            Impact factor:   5.571


  9 in total

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