| Literature DB >> 26952756 |
Vivek Pandey1, Anusha Singh2, Ajit Singh2, Amitabh Krishna2, Uma Pandey3, Yamini Bhusan Tripathi4.
Abstract
The aims of the current study were to examine the effects of temporal changes in oxidative stress (OS) and low-grade inflammation in letrozole-treated rats and to correlate these changes with the development of polycystic ovary syndrome (PCOS)-like features. Rats were treated with letrozole for 7, 15 and 21 days to induce PCOS. On day 7 of the treatment, a significant increase in serum testosterone and high sensitive C-reactive protein (hsCRP), the low-grade inflammatory marker, was found in the letrozole treated rats compared to control rats. Moreover, a decreased immunoexpression of insulin receptor coincided with increased body weight. The strong correlation between the levels of hsCRP and lipid peroxidation (LPO) suggests simultaneous development of low-grade inflammation and OS in response to hyperandrogenism, and the role of OS in a formation of cystic follicles in the letrozole animal PCOS model. Therefore, the results of the present study suggest that OS and low-grade inflammation (hsCRP) are the major causes of PCOS induction in this model.Entities:
Keywords: Inflammation; Insulin resistance; Oxidative stress; Polycystic ovary syndrome
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Year: 2016 PMID： 26952756 DOI： 10.1016/j.repbio.2015.12.005
Source DB: PubMed Journal: Reprod Biol ISSN： 1642-431X Impact factor: 2.376