| Literature DB >> 26952425 |
Miho Nakamura1, Naoko Hori2, Hiroshi Ando3, Saki Namba4, Takeshi Toyama3, Nobuyuki Nishimiya3, Kimihiro Yamashita2.
Abstract
The initial adhesion of cells to biomaterials is critical in the regulation of subsequent cell behaviors. The purpose of this study was to investigate a mechanism through which the surface wettability of biomaterials can be improved and determine the effects of biomaterial surface characteristics on cellular behaviors. We investigated the surface characteristics of various types of hydroxyapatite after sintering in different atmospheres and examined the effects of various surface characteristics on cell adhesion to study cell-biomaterial interactions. Sintering atmosphere affects the polarization capacity of hydroxyapatite by changing hydroxide ion content and grain size. Compared with hydroxyapatite sintered in air, hydroxyapatite sintered in saturated water vapor had a higher polarization capacity that increased surface free energy and improved wettability, which in turn accelerated cell adhesion. We determined the optimal conditions of hydroxyapatite polarization for the improvement of surface wettability and acceleration of cell adhesion.Entities:
Keywords: Cell adhesion; Hydroxyapatite; Surface characteristics; Surface free energy; Wettability
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Year: 2016 PMID： 26952425 DOI： 10.1016/j.msec.2016.01.037
Source DB: PubMed Journal: Mater Sci Eng C Mater Biol Appl ISSN： 0928-4931 Impact factor: 7.328