Imene D Ayadi1, Emira B H Nouaili2, Emna Talbi3, Aicha Ghdemssi2, Chiraz Rached4, Afef Bahlous3, Amel Gammoudi4, Sonia Ben Hamouda5, Badreddine Bouguerra5, Kehna Bouzid3, Jouda Abdelmoula3, Zahra Marrakchi2. 1. Department of Neonatology, Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia. Electronic address: imen_ayadi@hotmail.com. 2. Department of Neonatology, Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia. 3. Biochemistry Laboratory, Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia. 4. Department of Nutrition, National Institute of Nutrition, Tunis El Manar University, Tunis, Tunisia. 5. Department of Obstetrics and Gynecology, Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia.
Abstract
OBJECTIVE: To assess vitamin D status in mothers and their newborns and identify predictive factors of vitamin D deficiency. METHODS: A cross-sectional study was undertaken of healthy women and their full-term newborns delivered at the Charles Nicolle Hospital, Tunis, Tunisia, between October and November 2012. Maternal and neonatal serum 25-hydroxy vitamin D (25(OH)D) concentrations were measured. Correlations were tested. RESULTS: Overall, 87 mothers and their newborns were enrolled. No mother or neonate had an adequate vitamin D status. Mean maternal and neonatal serum 25(OH)D concentrations were 6.82±5.14ng/mL (range 3.60-23.77) and 5.92±4.15ng/mL (range 3.60-22.28), respectively. Vitamin D deficiency (serum 25(OH)D<20ng/mL) was found in 84 (97%) mothers and 85 (98%) neonates, of whom 76 (87%) and 78 (90%), respectively, had severe deficiency (serum 25(OH)D<12ng/mL). Maternal serum 25(OH)D showed a strong positive correlation with neonatal serum 25(OH)D (r=0.69, P<0.001). Maternal dietary vitamin D intake was the only factor shown to be associated with serum 25(OH)D concentrations (P<0.05). CONCLUSION: Vitamin D deficiency is prevalent among Tunisian mothers and their neonates.
OBJECTIVE: To assess vitamin D status in mothers and their newborns and identify predictive factors of vitamin D deficiency. METHODS: A cross-sectional study was undertaken of healthy women and their full-term newborns delivered at the Charles Nicolle Hospital, Tunis, Tunisia, between October and November 2012. Maternal and neonatal serum 25-hydroxy vitamin D (25(OH)D) concentrations were measured. Correlations were tested. RESULTS: Overall, 87 mothers and their newborns were enrolled. No mother or neonate had an adequate vitamin D status. Mean maternal and neonatal serum 25(OH)D concentrations were 6.82±5.14ng/mL (range 3.60-23.77) and 5.92±4.15ng/mL (range 3.60-22.28), respectively. Vitamin D deficiency (serum 25(OH)D<20ng/mL) was found in 84 (97%) mothers and 85 (98%) neonates, of whom 76 (87%) and 78 (90%), respectively, had severe deficiency (serum 25(OH)D<12ng/mL). Maternal serum 25(OH)D showed a strong positive correlation with neonatal serum 25(OH)D (r=0.69, P<0.001). Maternal dietary vitamin D intake was the only factor shown to be associated with serum 25(OH)D concentrations (P<0.05). CONCLUSION:Vitamin D deficiency is prevalent among Tunisian mothers and their neonates.
Authors: Andrea Giustina; Roger Bouillon; Neil Binkley; Christopher Sempos; Robert A Adler; Jens Bollerslev; Bess Dawson-Hughes; Peter R Ebeling; David Feldman; Annemieke Heijboer; Glenville Jones; Christopher S Kovacs; Marise Lazaretti-Castro; Paul Lips; Claudio Marcocci; Salvatore Minisola; Nicola Napoli; Rene Rizzoli; Robert Scragg; John H White; Anna Maria Formenti; John P Bilezikian Journal: JBMR Plus Date: 2020-11-10