| Literature DB >> 26951817 |
Amanda Farage Frade1, Laurie Laugier2, Ludmila Rodrigues Pinto Ferreira3, Monique Andrade Baron4, Luiz Alberto Benvenuti5, Priscila Camillo Teixeira4, Isabela Cunha Navarro4, Sandrine Cabantous2, Frederico Moraes Ferreira3, Darlan da Silva Cândido4, Fabio Antônio Gaiotto5, Fernando Bacal6, Pablo Pomerantzeff6, Ronaldo Honorato Barros Santos5, Jorge Kalil7, Edecio Cunha-Neto4, Christophe Chevillard2.
Abstract
Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.Entities:
Keywords: Chagas disease; MIAT; biomarker; cardiomyopathy; dilated; lncRNA
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Year: 2016 PMID： 26951817 DOI： 10.1093/infdis/jiw095
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226