Literature DB >> 26950761

Total Synthesis of Lycopalhine A.

Yuji Ochi1, Satoshi Yokoshima1, Tohru Fukuyama1.   

Abstract

The total synthesis of lycopalhine A has been accomplished. The synthesis features construction of the tricyclic system via cleavage of a cyclopropane ring and an ensuing intramolecular Michael addition, stereoselective introduction of a 2-aminoethyl moiety via a reaction of allyltrimethylsilane to a sulfonyliminium ion, and a stereoselective intramolecular aldol reaction.

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Year:  2016        PMID： 26950761     DOI： 10.1021/acs.orglett.6b00338

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

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  3 in total

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