| Literature DB >> 26950641 |
Atul A More1, Chepuri V Ramana1.
Abstract
The first total synthesis of integrastatin B, a potent HIV-1 integrase inhibitor, has been accomplished in seven steps with a 17.9% overall yield employing easily accessible starting compounds. The Oxone-mediated oxidative benzofuran dearomatization cascade has been employed as the key skeletal construct to forge the central tetracyclic nucleus.Entities:
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Year: 2016 PMID： 26950641 DOI： 10.1021/acs.orglett.6b00404
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005