| Literature DB >> 26948889 |
Marina Eliava1, Meggane Melchior2, H Sophie Knobloch-Bollmann3, Jérôme Wahis2, Miriam da Silva Gouveia1, Yan Tang4, Alexandru Cristian Ciobanu5, Rodrigo Triana Del Rio5, Lena C Roth3, Ferdinand Althammer1, Virginie Chavant2, Yannick Goumon2, Tim Gruber3, Nathalie Petit-Demoulière2, Marta Busnelli6, Bice Chini7, Linette L Tan8, Mariela Mitre9, Robert C Froemke9, Moses V Chao9, Günter Giese10, Rolf Sprengel10, Rohini Kuner8, Pierrick Poisbeau2, Peter H Seeburg10, Ron Stoop5, Alexandre Charlet11, Valery Grinevich12.
Abstract
Oxytocin (OT) is a neuropeptide elaborated by the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. Magnocellular OT neurons of these nuclei innervate numerous forebrain regions and release OT into the blood from the posterior pituitary. The PVN also harbors parvocellular OT cells that project to the brainstem and spinal cord, but their function has not been directly assessed. Here, we identified a subset of approximately 30 parvocellular OT neurons, with collateral projections onto magnocellular OT neurons and neurons of deep layers of the spinal cord. Evoked OT release from these OT neurons suppresses nociception and promotes analgesia in an animal model of inflammatory pain. Our findings identify a new population of OT neurons that modulates nociception in a two tier process: (1) directly by release of OT from axons onto sensory spinal cord neurons and inhibiting their activity and (2) indirectly by stimulating OT release from SON neurons into the periphery.Entities:
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Year: 2016 PMID： 26948889 PMCID： PMC5679079 DOI： 10.1016/j.neuron.2016.01.041
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173