Literature DB >> 26948067

Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy.

Chenggen Qian1,2,3, Jicheng Yu1,2, Yulei Chen3, Quanyin Hu1,2, Xuanzhong Xiao3, Wujin Sun1,2, Chao Wang1,2, Peijian Feng3, Qun-Dong Shen3, Zhen Gu1,2,4.   

Abstract

A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen ((1) O2 ) and inducing hypoxia to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy. This dual-responsive nanocarrier provides an innovative design guideline for enhancing traditional photodynamic therapeutic efficacy integrated with a controlled drug-release modality.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  conjugated polymers; drug delivery; hypoxia-responsive; nanomedicine; photodynamic therapy

Mesh：

Substances：

Year:  2016        PMID： 26948067      PMCID： PMC4998838          DOI： 10.1002/adma.201505869

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  49 in total

1.  Long-term in vivo performance and biocompatibility of poly(vinyl alcohol) hydrogel macrocapsules for hybrid-type artificial pancreas.

Authors:  K Burczak; E Gamian; A Kochman
Journal:  Biomaterials       Date:  1996-12       Impact factor: 12.479

2.  Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery.

Authors:  Jicheng Yu; Yuqi Zhang; Yanqi Ye; Rocco DiSanto; Wujin Sun; Davis Ranson; Frances S Ligler; John B Buse; Zhen Gu
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-22       Impact factor: 11.205

3.  pH-Responsive and near-infrared-emissive polymer nanoparticles for simultaneous delivery, release, and fluorescence tracking of doxorubicin in vivo.

Authors:  Ji-Cheng Yu; Yu-Lei Chen; Yu-Qi Zhang; Xi-Kuang Yao; Cheng-Gen Qian; Jun Huang; Sha Zhu; Xi-Qun Jiang; Qun-Dong Shen; Zhen Gu
Journal:  Chem Commun (Camb)       Date:  2014-05-11       Impact factor: 6.222

4.  Deep penetration of a PDT drug into tumors by noncovalent drug-gold nanoparticle conjugates.

Authors:  Yu Cheng; Joseph D Meyers; Ann-Marie Broome; Malcolm E Kenney; James P Basilion; Clemens Burda
Journal:  J Am Chem Soc       Date:  2011-02-04       Impact factor: 15.419

5.  Acid pH in tumors and its potential for therapeutic exploitation.

Authors:  I F Tannock; D Rotin
Journal:  Cancer Res       Date:  1989-08-15       Impact factor: 12.701

Review 6.  Photodynamic therapy for cancer.

Authors:  Dennis E J G J Dolmans; Dai Fukumura; Rakesh K Jain
Journal:  Nat Rev Cancer       Date:  2003-05       Impact factor: 60.716

7.  Gated silica mesoporous supports for controlled release and signaling applications.

Authors:  Carmen Coll; Andrea Bernardos; Ramón Martínez-Máñez; Félix Sancenón
Journal:  Acc Chem Res       Date:  2012-12-06       Impact factor: 22.384

8.  Relationship of tumor hypoxia and response to photodynamic treatment in an experimental mouse tumor.

Authors:  B W Henderson; V H Fingar
Journal:  Cancer Res       Date:  1987-06-15       Impact factor: 12.701

Review 9.  Nanocarriers as an emerging platform for cancer therapy.

Authors:  Dan Peer; Jeffrey M Karp; Seungpyo Hong; Omid C Farokhzad; Rimona Margalit; Robert Langer
Journal:  Nat Nanotechnol       Date:  2007-12       Impact factor: 39.213

10.  In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine.

Authors:  Feng Chen; Hao Hong; Shreya Goel; Stephen A Graves; Hakan Orbay; Emily B Ehlerding; Sixiang Shi; Charles P Theuer; Robert J Nickles; Weibo Cai
Journal:  ACS Nano       Date:  2015-04-08       Impact factor: 15.881
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  54 in total

1.  A Porous Au@Rh Bimetallic Core-Shell Nanostructure as an H2 O2 -Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy.

Authors:  Jinping Wang; Jingyu Sun; Wei Hu; Yuhao Wang; Tsengming Chou; Beilu Zhang; Qiang Zhang; Lei Ren; Hongjun Wang
Journal:  Adv Mater       Date:  2020-04-24       Impact factor: 30.849

Review 2.  Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light.

Authors:  Mahdi Karimi; Parham Sahandi Zangabad; Soodeh Baghaee-Ravari; Mehdi Ghazadeh; Hamid Mirshekari; Michael R Hamblin
Journal:  J Am Chem Soc       Date:  2017-03-13       Impact factor: 15.419

3.  Multifunctional Liposomes for Image-Guided Intratumoral Chemo-Phototherapy.

Authors:  Dyego Miranda; Kevin Carter; Dandan Luo; Shuai Shao; Jumin Geng; Changning Li; Upendra Chitgupi; Steven G Turowski; Nasi Li; G Ekin Atilla-Gokcumen; Joseph A Spernyak; Jonathan F Lovell
Journal:  Adv Healthc Mater       Date:  2017-05-15       Impact factor: 9.933

Review 4.  Advances in Stimulus-Responsive Polymeric Materials for Systemic Delivery of Nucleic Acids.

Authors:  Minjie Sun; Kaikai Wang; David Oupický
Journal:  Adv Healthc Mater       Date:  2017-12-11       Impact factor: 9.933

5.  Therapeutic Nanosystem Consisting of Singlet-Oxygen-Responsive Prodrug and Photosensitizer Excited by Two-Photon Light.

Authors:  Yi Lin; Xiao-Fang Jiang; Xiangyan Duan; Fang Zeng; Bo Wu; Shuizhu Wu
Journal:  ACS Med Chem Lett       Date:  2017-12-22       Impact factor: 4.345

Review 6.  Membrane-core nanoparticles for cancer nanomedicine.

Authors:  Jianfeng Guo; Leaf Huang
Journal:  Adv Drug Deliv Rev       Date:  2020-05-22       Impact factor: 15.470

7.  Molecular afterglow imaging with bright, biodegradable polymer nanoparticles.

Authors:  Qingqing Miao; Chen Xie; Xu Zhen; Yan Lyu; Hongwei Duan; Xiaogang Liu; Jesse V Jokerst; Kanyi Pu
Journal:  Nat Biotechnol       Date:  2017-10-16       Impact factor: 54.908

8.  Dual Hypoxia-Targeting RNAi Nanomedicine for Precision Cancer Therapy.

Authors:  Yujing Li; Jianxun Ding; Xiaoding Xu; Run Shi; Phei Er Saw; Junqing Wang; Shirley Chung; Wenliang Li; Bader M Aljaeid; Robert J Lee; Wei Tao; Lesheng Teng; Omid C Farokhzad; Jinjun Shi
Journal:  Nano Lett       Date:  2020-06-08       Impact factor: 11.189

Review 9.  Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment.

Authors:  Yunlu Dai; Can Xu; Xiaolian Sun; Xiaoyuan Chen
Journal:  Chem Soc Rev       Date:  2017-05-18       Impact factor: 54.564

10.  Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance.

Authors:  Xiang Ling; Xing Chen; Imogen A Riddell; Wei Tao; Junqing Wang; Geoffrey Hollett; Stephen J Lippard; Omid C Farokhzad; Jinjun Shi; Jun Wu
Journal:  Nano Lett       Date:  2018-06-19       Impact factor: 11.189
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