Mara E DiBartolomeo1, Erika C Claud2. 1. The University of Chicago, Chicago, Illinois. 2. The University of Chicago, Chicago, Illinois. Electronic address: eclaud@peds.bsd.uchicago.edu.
Abstract
PURPOSE: To determine the importance of the neonatal microbiome in intestinal and overall health. METHOD: A review of existing literature. FINDINGS AND IMPLICATIONS: The microbiome is increasingly understood to have a significant role in health and disease. However, the microbiome of the preterm infant is unique, with simple microbial communities exposed to a consistent diet in a regulated environment, and development from naive to stable under the influence of the neonatal intensive care unit. This early microbiome encounters a still developing host and thus has the potential to program fundamental pathways with implications for neonatal and later outcomes.
PURPOSE: To determine the importance of the neonatal microbiome in intestinal and overall health. METHOD: A review of existing literature. FINDINGS AND IMPLICATIONS: The microbiome is increasingly understood to have a significant role in health and disease. However, the microbiome of the preterm infant is unique, with simple microbial communities exposed to a consistent diet in a regulated environment, and development from naive to stable under the influence of the neonatal intensive care unit. This early microbiome encounters a still developing host and thus has the potential to program fundamental pathways with implications for neonatal and later outcomes.
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