Ann M Davis1, Kelsey Dean2, Hayat Mousa3, Sarah Edwards4, Jose Cocjin4, Osama Almadhoun5, Jianghua He6, Amanda Bruce7, Paul E Hyman8. 1. Department of Pediatrics, University of Kansas Medical Center, Kansas City, KS; Center for Children's Healthy Lifestyles and Nutrition, Kansas City, MO. Electronic address: Adavis6@kumc.edu. 2. Center for Children's Healthy Lifestyles and Nutrition, Kansas City, MO. 3. Pediatric Gastroenterology, Hepatology and Nutrition Department, University of California San Diego/Rady Children's Hospital, San Diego, CA. 4. Pediatric Gastroenterology, Children's Mercy Kansas City, Kansas City, MO. 5. Department of Pediatrics, University of Kansas Medical Center, Kansas City, KS. 6. Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS. 7. Department of Pediatrics, University of Kansas Medical Center, Kansas City, KS; Center for Children's Healthy Lifestyles and Nutrition, Kansas City, MO. 8. New Orleans Children's Hospital, New Orleans, LA.
Abstract
OBJECTIVE: To assess the role of amitriptyline in the effectiveness of an outpatient protocol for weaning medically complicated children from tube to oral feeding. STUDY DESIGN:Twenty-one children seen in multidisciplinary outpatient feeding teams across 4 sites were recruited to a randomizedplacebo-controlled trial of a 6-month outpatient treatment protocol with behavioral, oral-motor, nutrition, and medication components. RESULTS: All of the children who completed the 6-month program (73%) were weaned to receive only oral feeding, regardless of group assignment. The transition from tube to oral feeding resulted in decreases in body mass index percentile and pain, some improvements in quality of life, and no statistically significant changes in cost. CONCLUSIONS:Amitriptyline is not a key component of this otherwise effective outpatient, interdisciplinary protocol for weaning children from tube to oral feeding. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01206478.
RCT Entities:
OBJECTIVE: To assess the role of amitriptyline in the effectiveness of an outpatient protocol for weaning medically complicated children from tube to oral feeding. STUDY DESIGN: Twenty-one children seen in multidisciplinary outpatient feeding teams across 4 sites were recruited to a randomized placebo-controlled trial of a 6-month outpatient treatment protocol with behavioral, oral-motor, nutrition, and medication components. RESULTS: All of the children who completed the 6-month program (73%) were weaned to receive only oral feeding, regardless of group assignment. The transition from tube to oral feeding resulted in decreases in body mass index percentile and pain, some improvements in quality of life, and no statistically significant changes in cost. CONCLUSIONS:Amitriptyline is not a key component of this otherwise effective outpatient, interdisciplinary protocol for weaning children from tube to oral feeding. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01206478.
Authors: Sarah Edwards; Ann McGrath Davis; Linda Ernst; Brenda Sitzmann; Amanda Bruce; David Keeler; Osama Almadhoun; Hayat Mousa; Paul Hyman Journal: JPEN J Parenter Enteral Nutr Date: 2015-11 Impact factor: 4.016
Authors: Caroline M Hartdorff; C M Frank Kneepkens; Anita M Stok-Akerboom; Elisabeth M van Dijk-Lokkart; Michelle A H Engels; Angelika Kindermann Journal: J Pediatr Gastroenterol Nutr Date: 2015-04 Impact factor: 2.839
Authors: Jeanne M Landgraf; Ineke Vogel; Rianne Oostenbrink; Margriet E van Baar; Hein Raat Journal: Qual Life Res Date: 2012-04-17 Impact factor: 4.147
Authors: Andrea M Garcia; Marshall T Beauchamp; Susana R Patton; Sarah Edwards; Meredith L Dreyer Gillette; Ann M Davis Journal: J Health Psychol Date: 2020-12-18
Authors: Sarah Edwards; Paul E Hyman; Hayat Mousa; Amanda Bruce; Jose Cocjin; Kelsey Dean; Kandace Fleming; Rebecca Swinburne Romine; Ann M Davis Journal: Trials Date: 2021-02-27 Impact factor: 2.279