Literature DB >> 26947459

Cyclization and unsaturation rather than isomerisation of side chains govern the selective antibacterial activity of cationic-amphiphilic polymers.

D S S M Uppu1, M Bhowmik1, S Samaddar1, J Haldar1.   

Abstract

Membrane-active agents represent a promising alternative to overcome antibiotic resistance. Here, we report cationic-amphiphilic polymers with variations in the side chain architecture such as cyclization, isomerization and unsaturation that resulted in potent antibacterial activity and low mammalian cell toxicity with a membrane-active mode of action.

Entities:  

Year:  2016        PMID： 26947459     DOI： 10.1039/c5cc09930g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Comparison of the equilibrium, kinetic and water exchange properties of some metal ion-DOTA and DOTA-bis(amide) complexes.

Authors:  Gyula Tircsó; Enikő Tircsóné Benyó; Zoltán Garda; Jaspal Singh; Robert Trokowski; Ernő Brücher; A Dean Sherry; Éva Tóth; Zoltán Kovács
Journal:  J Inorg Biochem       Date:  2020-02-20       Impact factor: 4.155

2.  More QACs, more questions: Recent advances in structure activity relationships and hurdles in understanding resistance mechanisms.

Authors:  Kelly R Morrison; Ryan A Allen; Kevin P C Minbiole; William M Wuest
Journal:  Tetrahedron Lett       Date:  2019-07-26       Impact factor: 2.415

3.  Membrane-active macromolecules kill antibiotic-tolerant bacteria and potentiate antibiotics towards Gram-negative bacteria.

Authors:  Divakara S S M Uppu; Mohini M Konai; Paramita Sarkar; Sandip Samaddar; Isabel C M Fensterseifer; Celio Farias-Junior; Paramanandam Krishnamoorthy; Bibek R Shome; Octávio L Franco; Jayanta Haldar
Journal:  PLoS One       Date:  2017-08-24       Impact factor: 3.240

4.  Isosteric substitution in cationic-amphiphilic polymers reveals an important role for hydrogen bonding in bacterial membrane interactions.

Authors:  D S S M Uppu; M M Konai; U Baul; P Singh; T K Siersma; S Samaddar; S Vemparala; L W Hamoen; C Narayana; J Haldar
Journal:  Chem Sci       Date:  2016-04-07       Impact factor: 9.825

5.  Side-Chain Amino Acid-Based Cationic Antibacterial Polymers: Investigating the Morphological Switching of a Polymer-Treated Bacterial Cell.

Authors:  Ishita Mukherjee; Anwesha Ghosh; Punyasloke Bhadury; Priyadarsi De
Journal:  ACS Omega       Date:  2017-04-25

6.  Leucine-Based Polymer Architecture-Induced Antimicrobial Properties and Bacterial Cell Morphology Switching.

Authors:  Ishita Mukherjee; Anwesha Ghosh; Punyasloke Bhadury; Priyadarsi De
Journal:  ACS Omega       Date:  2018-01-22

Review 7.  Polymeric approach to combat drug-resistant methicillin-resistant Staphylococcus aureus.

Authors:  Shreya Kanth; Akshatha Nagaraja; Yashoda Malgar Puttaiahgowda
Journal:  J Mater Sci       Date:  2021-01-25       Impact factor: 4.220
  7 in total

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