Héctor Rangel-Villalobos1, Víctor Manuel Martínez-Sevilla1, Gabriela Martínez-Cortés1, José Alonso Aguilar-Velázquez1, Martha Sosa-Macías2, Rodrigo Rubi-Castellanos3, Antonio González-Martín4. 1. Instituto De Investigación En Genética Molecular, Centro Universitario De La Ciénega (CUCI-UdeG), Ocotlán, Jalisco, México. 2. Unidad Durango (CIIDIR-IPN), Centro Interdisciplinario De Investigación Para El Desarrollo Integral Regional Del Instituto Politécnico Nacional, Durango, México. 3. Laboratorio De Genética, Centro De Investigaciones Regionales Hideyo Noguchi, Universidad Autónoma De Yucatán (UADY), Mérida, Yucatán. 4. Departamento De Zoología Y Antropología Física, Facultad De Biología, Universidad Complutense De Madrid, Madrid, Spain.
Abstract
OBJECTIVE: To analyze the origin, structure, relationships, and recent admixture in Mexican Native groups based on 15 STRs commonly used in human identification. METHODS: We analyzed 39 Mexican Native population samples using STR databases based on the AmpFlSTR® Identifiler kit (n = 3,135), including Mexican-Mestizos (admixed), European and African populations, as reference. RESULTS: Based upon effective population size (Ne) differences, Native groups were clustered into three regions: i) Center-Southeast groups, characterized by larger Ne, migration rate (Nm), genetic diversity (He), and relative homogeneity principally in the Yucatan Peninsula; ii) Isolated southern groups from Chiapas and Oaxaca, characterized by lower Ne, Nm, and He (i.e. higher isolation and genetic differentiation); iii) North-Northwest groups, which are similar to the previous group but are characterized by generating the widest gene flow barrier in the Pre-Hispanic Mexican territory, and currently by elevated admixture in some northern Native groups. Despite the relative congruence between genetic relationships with cultural, linguistic, geographic criteria, these factors do not explain the present-day population structure of Native groups, excepting in those linguistically related to the Mayan that show higher homogeneity. The Isolation by distance model was demonstrated at long distances (>1,500 km), whereas geographic isolation stands as a determining factor to avoid both non-indigenous admixture and bottleneck processes. CONCLUSIONS: Different dynamics of gene flow and drift were observed among Mexican Native groups, highlighting the geographic barriers (mountains, canyons and jungle regions) as the main factor differentiating Pre-Hispanic populations, and eventually helping to avoid Post-European contact admixture and population bottleneck. Am J Phys Anthropol 160:298-316, 2016.
OBJECTIVE: To analyze the origin, structure, relationships, and recent admixture in Mexican Native groups based on 15 STRs commonly used in human identification. METHODS: We analyzed 39 Mexican Native population samples using STR databases based on the AmpFlSTR® Identifiler kit (n = 3,135), including Mexican-Mestizos (admixed), European and African populations, as reference. RESULTS: Based upon effective population size (Ne) differences, Native groups were clustered into three regions: i) Center-Southeast groups, characterized by larger Ne, migration rate (Nm), genetic diversity (He), and relative homogeneity principally in the Yucatan Peninsula; ii) Isolated southern groups from Chiapas and Oaxaca, characterized by lower Ne, Nm, and He (i.e. higher isolation and genetic differentiation); iii) North-Northwest groups, which are similar to the previous group but are characterized by generating the widest gene flow barrier in the Pre-Hispanic Mexican territory, and currently by elevated admixture in some northern Native groups. Despite the relative congruence between genetic relationships with cultural, linguistic, geographic criteria, these factors do not explain the present-day population structure of Native groups, excepting in those linguistically related to the Mayan that show higher homogeneity. The Isolation by distance model was demonstrated at long distances (>1,500 km), whereas geographic isolation stands as a determining factor to avoid both non-indigenous admixture and bottleneck processes. CONCLUSIONS: Different dynamics of gene flow and drift were observed among Mexican Native groups, highlighting the geographic barriers (mountains, canyons and jungle regions) as the main factor differentiating Pre-Hispanic populations, and eventually helping to avoid Post-European contact admixture and population bottleneck. Am J Phys Anthropol 160:298-316, 2016.
Authors: G Martínez-Cortés; F Zuñiga-Chiquette; A S Celorio-Sánchez; E Ruiz García; A B Antelo-Figueroa; V Dalpozzo-Valenzuela; A Valenzuela-Coronado; H Rangel-Villalobos Journal: Int J Legal Med Date: 2018-10-17 Impact factor: 2.686
Authors: J A Aguilar-Velázquez; G Martínez-Cortés; A Inclán-Sánchez; A F Favela-Mendoza; J S Velarde-Félix; H Rangel-Villalobos Journal: Int J Legal Med Date: 2018-03-01 Impact factor: 2.686
Authors: Claudia Ojeda-Granados; Paolo Abondio; Alice Setti; Stefania Sarno; Guido Alberto Gnecchi-Ruscone; Eduardo González-Orozco; Sara De Fanti; Andres Jiménez-Kaufmann; Héctor Rangel-Villalobos; Andrés Moreno-Estrada; Marco Sazzini Journal: Mol Biol Evol Date: 2022-01-07 Impact factor: 16.240