Lulu Yu1, Lan Wang1, Xiaochuan Zhao1, Mei Song1, Xueyi Wang2. 1. Department of Psychiatry, First Hospital of the Hebei Medical University, China; Mental Health Institute of the Hebei Medical University, China. 2. Department of Psychiatry, First Hospital of the Hebei Medical University, China; Mental Health Institute of the Hebei Medical University, China. Electronic address: ydyywxy@163.corn.
Abstract
AIMS: Previous studies showed that exposure to certain types of stressors enhance the rewarding effects of many drugs of abuse, including alcohol; however, no systematic study has investigated the role of single prolonged stress (SPS) in acquisition of alcohol conditioned place preference (CPP). The purpose of this study was to examine whether SPS would facilitate the acquisition of alcohol CPP in rats. MAIN METHODS: Male Sprague-Dawley rats were randomly assigned to either SPS exposure condition or no exposure condition. Freezing behavior and Elevated plus maze (EPM) were employed to evaluate PTSD-like symptoms induced by SPS. Further, using unbiased procedure, CPP conditioning was conducted with alcohol (2g/kg). KEY FINDINGS: SPS significantly enhanced freezing behavior of rats, decreased percentages (%) of both time spent and number of entry into the open arms, and facilitated the acquisition of alcohol CPP without inhibiting rats' activity. SIGNIFICANCE: Our findings suggest that SPS plays an important role in alcohol dependence, and CPP paradigm with SPS may be useful for exploring the rewarding mechanism of alcohol with regard to the interaction between alcohol and post-traumatic stress disorder (PTSD).
AIMS: Previous studies showed that exposure to certain types of stressors enhance the rewarding effects of many drugs of abuse, including alcohol; however, no systematic study has investigated the role of single prolonged stress (SPS) in acquisition of alcohol conditioned place preference (CPP). The purpose of this study was to examine whether SPS would facilitate the acquisition of alcohol CPP in rats. MAIN METHODS: Male Sprague-Dawley rats were randomly assigned to either SPS exposure condition or no exposure condition. Freezing behavior and Elevated plus maze (EPM) were employed to evaluate PTSD-like symptoms induced by SPS. Further, using unbiased procedure, CPP conditioning was conducted with alcohol (2g/kg). KEY FINDINGS:SPS significantly enhanced freezing behavior of rats, decreased percentages (%) of both time spent and number of entry into the open arms, and facilitated the acquisition of alcohol CPP without inhibiting rats' activity. SIGNIFICANCE: Our findings suggest that SPS plays an important role in alcohol dependence, and CPP paradigm with SPS may be useful for exploring the rewarding mechanism of alcohol with regard to the interaction between alcohol and post-traumatic stress disorder (PTSD).
Authors: Chantelle Ferland-Beckham; Lauren E Chaby; Nikolaos P Daskalakis; Dayan Knox; Israel Liberzon; Miranda M Lim; Christa McIntyre; Shane A Perrine; Victoria B Risbrough; Esther L Sabban; Andreas Jeromin; Magali Haas Journal: Front Behav Neurosci Date: 2021-05-14 Impact factor: 3.558
Authors: Michael J Lisieski; Andrew L Eagle; Alana C Conti; Israel Liberzon; Shane A Perrine Journal: Front Psychiatry Date: 2018-05-15 Impact factor: 4.157