| Literature DB >> 26945691 |
D N Morand1,2, J-L Davideau1,2, F Clauss1,2, N Jessel1, H Tenenbaum1,2, O Huck1,2.
Abstract
Regeneration of periodontal tissues is one of the main goals of periodontal therapy. However, current treatment, including surgical approach, use of membrane to allow maturation of all periodontal tissues, or use of enamel matrix derivatives, presents limitations in their indications and outcomes leading to the development of new tissue engineering strategies. Several cytokines are considered as key molecules during periodontal destruction process. However, their role during each phase of periodontal wound healing remains unclear. Control and modulation of the inflammatory response and especially, release of cytokines or activation/inhibition in a time- and spatial-controlled manner may be a potential perspective for periodontal tissue engineering. The aim of this review was to summarize the specific role of several cytokines during periodontal wound healing and the potential therapeutic interest of inflammatory modulation for periodontal regeneration especially related to the expression sequence of cytokines.Keywords: cytokines; periodontitis; regenerative medicine; scaffold; wound healing
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Year: 2016 PMID： 26945691 DOI： 10.1111/odi.12469
Source DB: PubMed Journal: Oral Dis ISSN： 1354-523X Impact factor: 3.511