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Literature DB >> 26945625

Structure and function of the AAA+ ATPase p97/Cdc48p.

Abstract

p97 (also known as valosin-containing protein (VCP) in mammals or Cdc48p in Saccharomyces cerevisiae) is an evolutionarily conserved ATPase present in all eukaryotes and archaebacteria. In conjunction with a collection of cofactors and adaptors, p97/Cdc48p performs an array of biological functions mostly through modulating the stability of 'client' proteins. Using energy from ATP hydrolysis, p97/Cdc48p segregates these molecules from immobile cellular structures such as protein assemblies, membrane organelles, and chromatin. Consequently, the released polypeptides can be efficiently degraded by the ubiquitin proteasome system or recycled. This review summarizes our current understanding of the structure and function of this essential cellular chaperoning system. Published by Elsevier B.V.

Entities: Chemical Disease Gene Mutation Species

Keywords: AAA+ ATPase; Chromatin-associated degradation; ER-associated degradation; Membrane fusion; Mitochondria-associated degradation; Proteasome; Protein quality control; Ribosome-associated degradation; Segregase; Ubiquitin; Unfoldase; p97/CDC48

Mesh：

Substances：

Year: 2016 PMID： 26945625 PMCID： PMC4821690 DOI： 10.1016/j.gene.2016.02.042

Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688

153 in total

1. Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP.

Authors: S K Singh; R Grimaud; J R Hoskins; S Wickner; M R Maurizi
Journal: Proc Natl Acad Sci U S A Date: 2000-08-01 Impact factor: 11.205

Review 2. AAA+ superfamily ATPases: common structure--diverse function.

Authors: T Ogura; A J Wilkinson
Journal: Genes Cells Date: 2001-07 Impact factor: 1.891

3. A major conformational change in p97 AAA ATPase upon ATP binding.

Authors: I Rouiller; V M Butel; M Latterich; R A Milligan; E M Wilson-Kubalek
Journal: Mol Cell Date: 2000-12 Impact factor: 17.970

4. Structure of the AAA ATPase p97.

Authors: X Zhang; A Shaw; P A Bates; R H Newman; B Gowen; E Orlova; M A Gorman; H Kondo; P Dokurno; J Lally; G Leonard; H Meyer; M van Heel; P S Freemont
Journal: Mol Cell Date: 2000-12 Impact factor: 17.970

5. The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation.

Authors: A L Hitchcock; H Krebber; S Frietze; A Lin; M Latterich; P A Silver
Journal: Mol Biol Cell Date: 2001-10 Impact factor: 4.138

6. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways.

Authors: H H Meyer; J G Shorter; J Seemann; D Pappin; G Warren
Journal: EMBO J Date: 2000-05-15 Impact factor: 11.598

7. Clinical and molecular studies in a unique family with autosomal dominant limb-girdle muscular dystrophy and Paget disease of bone.

Authors: V E Kimonis; M J Kovach; B Waggoner; S Leal; A Salam; L Rimer; K Davis; R Khardori; D Gelber
Journal: Genet Med Date: 2000 Jul-Aug Impact factor: 8.822

8. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress.

Authors: Onn Brandman; Jacob Stewart-Ornstein; Daisy Wong; Adam Larson; Christopher C Williams; Gene-Wei Li; Sharleen Zhou; David King; Peter S Shen; Jimena Weibezahn; Joshua G Dunn; Silvi Rouskin; Toshifumi Inada; Adam Frost; Jonathan S Weissman
Journal: Cell Date: 2012-11-21 Impact factor: 41.582

9. Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase.

Authors: Tsui-Fen Chou; Kelin Li; Kevin J Frankowski; Frank J Schoenen; Raymond J Deshaies
Journal: ChemMedChem Date: 2013-01-11 Impact factor: 3.466

10. Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.

Authors: Rati Verma; Robert S Oania; Natalie J Kolawa; Raymond J Deshaies
Journal: Elife Date: 2013-01-22 Impact factor: 8.140

74 in total

1. UBE2O remodels the proteome during terminal erythroid differentiation.

Authors: Anthony T Nguyen; Miguel A Prado; Paul J Schmidt; Anoop K Sendamarai; Joshua T Wilson-Grady; Mingwei Min; Dean R Campagna; Geng Tian; Yuan Shi; Verena Dederer; Mona Kawan; Nathalie Kuehnle; Joao A Paulo; Yu Yao; Mitchell J Weiss; Monica J Justice; Steven P Gygi; Mark D Fleming; Daniel Finley
Journal: Science Date: 2017-08-04 Impact factor: 47.728

2. Cdc48/VCP and Endocytosis Regulate TDP-43 and FUS Toxicity and Turnover.

Authors: Guangbo Liu; Aaron Byrd; Amanda N Warner; Fen Pei; Eman Basha; Allison Buchanan; J Ross Buchan
Journal: Mol Cell Biol Date: 2020-01-30 Impact factor: 4.272

Review 3. Substrate selection by the proteasome through initiation regions.

Authors: Takuya Tomita; Andreas Matouschek
Journal: Protein Sci Date: 2019-05-23 Impact factor: 6.725

4. A Cdc48 "Retrochaperone" Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates.

Authors: Sonya Neal; Raymond Mak; Eric J Bennett; Randolph Hampton
Journal: J Biol Chem Date: 2017-01-11 Impact factor: 5.157

10. Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis.

Authors: Justin T Marinko; Hui Huang; Wesley D Penn; John A Capra; Jonathan P Schlebach; Charles R Sanders
Journal: Chem Rev Date: 2019-01-04 Impact factor: 60.622