| Literature DB >> 26945581 |
Shamik Chakraborty1,2, Christopher G Filippi2, Tamika Wong1, Ashley Ray1, Sherese Fralin1, A John Tsiouris3, Bidyut Praminick2, Alexis Demopoulos1,2, Heather J McCrea3, Imithri Bodhinayake1, Rafael Ortiz1,2, David J Langer1,2, John A Boockvar4,5,6.
Abstract
Objective To establish a maximum tolerated dose of superselective intraarterial cerebral infusion (SIACI) of Cetuximab after osmotic disruption of the blood-brain barrier (BBB) with mannitol, and examine safety of the procedure in patients with recurrent malignant glioma. Methods A total of 15 patients with recurrent malignant glioma were included in the current study. The starting dose of Cetuximab was 100 mg/m(2) and dose escalation was done to 250 mg/m(2). All patients were observed for 28 days post-infusion for any side effects. Results There was no dose-limiting toxicity from a single dose of SIACI of Cetuximab up to 250 mg/m(2) after osmotic BBB disruption with mannitol. A tolerable rash was seen in 2 patients, anaphylaxis in 1 patient, isolated seizure in 1 patient, and seizure and cerebral edema in 1 patient. Discussion SIACI of mannitol followed by Cetuximab (up to 250 mg/m(2)) for recurrent malignant glioma is safe and well tolerated. A Phase I/II trial is currently underway to determine the efficacy of SIACI of cetuximab in patients with high-grade glioma.Entities:
Keywords: Brain neoplasm; Cetuximab; Glioma; Intraarterial infusion; Mannitol
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Year: 2016 PMID： 26945581 DOI： 10.1007/s11060-016-2099-8
Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130