Literature DB >> 26945179

Brief Report: Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection.

Jennifer C Price1, Eric C Seaberg, John P Phair, Mallory D Witt, Susan L Koletar, Chloe L Thio.   

Abstract

To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre- and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Before HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA of <500 copies per milliliter: 16% for HIV-monoinfected and 22% for coinfected men. Decreases in APRI were dependent on HIV suppression. This protective effect of HAART decreased after 2 years, particularly in the HIV-monoinfected men.

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Year:  2016        PMID： 26945179      PMCID： PMC4911239          DOI： 10.1097/QAI.0000000000000981

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr        ISSN： 1525-4135            Impact factor:   3.731


  38 in total

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2.  Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: implications for the pathogenesis of HIV/hepatitis C virus-induced liver fibrosis.

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Journal:  Hepatology       Date:  2010-08       Impact factor: 17.425

3.  Is there evidence for an increase in the death rate from liver-related disease in patients with HIV?

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Journal:  AIDS       Date:  2005-12-02       Impact factor: 4.177

4.  Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study.

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Journal:  Arch Intern Med       Date:  2006 Aug 14-28

5.  Evaluation of liver fibrosis: concordance analysis between noninvasive scores (APRI and FIB-4) evolution and predictors in a cohort of HIV-infected patients without hepatitis C and B infection.

Authors:  Monia Mendeni; Emanuele Focà; Daria Gotti; Nicoletta Ladisa; Gioacchino Angarano; Laura Albini; Filippo Castelnuovo; Giampiero Carosi; Eugenia Quiros-Roldan; Carlo Torti
Journal:  Clin Infect Dis       Date:  2011-05       Impact factor: 9.079

6.  HIV mono-infection is associated with FIB-4 - A noninvasive index of liver fibrosis - in women.

Authors:  Jason T Blackard; Jeffrey A Welge; Lynn E Taylor; Kenneth H Mayer; Robert S Klein; David D Celentano; Denise J Jamieson; Lytt Gardner; Kenneth E Sherman
Journal:  Clin Infect Dis       Date:  2011-01-19       Impact factor: 9.079

7.  Predictors of the isolated hepatitis B core antibody pattern in HIV-infected and -uninfected men in the multicenter AIDS cohort study.

Authors:  Mallory D Witt; Roger J Lewis; Gunter Rieg; Eric C Seaberg; Charles R Rinaldo; Chloe L Thio
Journal:  Clin Infect Dis       Date:  2012-10-22       Impact factor: 9.079

Review 8.  Coinfection with HIV-1 and HCV--a one-two punch.

Authors:  Arthur Y Kim; Raymond T Chung
Journal:  Gastroenterology       Date:  2009-06-21       Impact factor: 22.682

9.  The Multicenter AIDS Cohort Study: retention after 9 1/2 years.

Authors:  J Dudley; S Jin; D Hoover; S Metz; R Thackeray; J Chmiel
Journal:  Am J Epidemiol       Date:  1995-08-01       Impact factor: 4.897

10.  Risk factors for fatty liver in the Multicenter AIDS Cohort Study.

Authors:  Jennifer C Price; Eric C Seaberg; Rachel Latanich; Matthew J Budoff; Lawrence A Kingsley; Frank J Palella; Mallory D Witt; Wendy S Post; Chloe L Thio
Journal:  Am J Gastroenterol       Date:  2014-03-18       Impact factor: 10.864
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  3 in total

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Authors:  Kenneth E Sherman; Enass Abdel-Hameed; Susan D Rouster; Mohamed Tarek M Shata; Jason T Blackard; Parham Safaie; Barbara Kroner; Liliana Preiss; Paul S Horn; Shyam Kottilil
Journal:  Clin Infect Dis       Date:  2019-05-17       Impact factor: 9.079

2.  Comparison of Hepatitis B Virus Infection in HIV-Infected and HIV-Uninfected Participants Enrolled in a Multinational Clinical Trial: HPTN 052.

Authors:  Amy E Greer; San-San Ou; Ethan Wilson; Estelle Piwowar-Manning; Michael S Forman; Marybeth McCauley; Theresa Gamble; Cholticha Ruangyuttikarn; Mina C Hosseinipour; Nagalingeswaran Kumarasamy; Mulinda Nyirenda; Beatriz Grinsztejn; Jose Henrique Pilotto; Natthapol Kosashunhanan; Marineide Gonçalves de Melo; Joseph Makhema; Victor Akelo; Ravindre Panchia; Sharlaa Badal-Faesen; Ying Q Chen; Myron S Cohen; Susan H Eshleman; Chloe L Thio; Alexandra Valsamakis
Journal:  J Acquir Immune Defic Syndr       Date:  2017-12-01       Impact factor: 3.731

Review 3.  A Tale of Two Viruses: Immunological Insights Into HCV/HIV Coinfection.

Authors:  Samaa T Gobran; Petronela Ancuta; Naglaa H Shoukry
Journal:  Front Immunol       Date:  2021-08-12       Impact factor: 7.561
  3 in total

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