Raviraj Purohit1, Sanjeev S Rao2, Jagdish P Goyal3, Vijay B Shah2, Jaykaran Charan4. 1. Department of Pediatrics, Civil Hospital, Deesa, Gujarat, India. 2. Department of Pediatrics, Govt Medical College, Surat, Gujarat, India. 3. Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249201, India. jpgoyal@rediffmail.com. 4. Department of Pharmacology, GMERS Medical College, Patan, Gujarat, India.
Abstract
OBJECTIVE: To determine pulmonary function abnormalities in children with Sickle Cell Disease (SCD) from Western India. METHODS: In this cross sectional study conducted at Surat, Gujarat, India; equal number of age and gender matched children i.e., 99 in the age group of 6-18 y was recruited in case (children with SCD) and control (non-SCD healthy children) groups respectively. Weight, height, body mass index (BMI) and hemoglobin (Hb) were assessed as baseline characteristics and spirometry was performed to assess the pulmonary function. RESULTS: The two groups of children were comparable in the baseline characteristics such as weight, height and BMI, however mean hemoglobin was significantly low in SCD as compared to healthy controls [9.1 ± 1.52 vs. 11.4 ± 1.04 (p=0.001)]. Mean (% predicted) Forced expiratory volume in 1 s (FEV1) (86.79 ± 11.6 vs. 94.3 ± 16.1) and FVC (84.4 ± 11.5 vs. 91.75 ± 15.2) values were significantly low (p < 0.001) in cases. CONCLUSIONS: The present study revealed that the difference of pulmonary function tests between sickle cell patients and normal age matched controls were statistically significant but this difference was not clinically significant.
OBJECTIVE: To determine pulmonary function abnormalities in children with Sickle Cell Disease (SCD) from Western India. METHODS: In this cross sectional study conducted at Surat, Gujarat, India; equal number of age and gender matched children i.e., 99 in the age group of 6-18 y was recruited in case (children with SCD) and control (non-SCD healthy children) groups respectively. Weight, height, body mass index (BMI) and hemoglobin (Hb) were assessed as baseline characteristics and spirometry was performed to assess the pulmonary function. RESULTS: The two groups of children were comparable in the baseline characteristics such as weight, height and BMI, however mean hemoglobin was significantly low in SCD as compared to healthy controls [9.1 ± 1.52 vs. 11.4 ± 1.04 (p=0.001)]. Mean (% predicted) Forced expiratory volume in 1 s (FEV1) (86.79 ± 11.6 vs. 94.3 ± 16.1) and FVC (84.4 ± 11.5 vs. 91.75 ± 15.2) values were significantly low (p < 0.001) in cases. CONCLUSIONS: The present study revealed that the difference of pulmonary function tests between sickle cell patients and normal age matched controls were statistically significant but this difference was not clinically significant.
Entities:
Keywords:
Children; India; Pulmonary function tests; Sickle cell disease