| Literature DB >> 26944295 |
Fernando Caravaggio1, Gagan Fervaha1, Jun Ku Chung1, Philip Gerretsen2, Shinichiro Nakajima3, Eric Plitman1, Yusuke Iwata1, Alan Wilson2, Ariel Graff-Guerrero4.
Abstract
While several studies have examined how particular personality traits are related to dopamine D2/3 receptor (D2/3R) availability in the striatum of humans, few studies have reported how multiple traits measured in the same persons are differentially related to D2/3R availability in different striatal sub-regions. We examined how personality traits measured with the Karolinska Scales of Personality are related to striatal D2/3R availability measured with [(11)C]-raclopride in 30 healthy humans. Based on previous the literature, five personality traits were hypothesized to be most likely related to D2/3R availability: impulsiveness, monotony avoidance, detachment, social desirability, and socialization. We found self-reported impulsiveness was negatively correlated with D2/3R availability in the ventral striatum and globus pallidus. After controlling for age and gender, monotony avoidance was also negatively correlated with D2/3R availability in the ventral striatum and globus pallidus. Socialization was positively correlated with D2/3R availability in the ventral striatum and putamen. After controlling for age and gender, the relationship between socialization and D2/3R availability in these regions survived correction for multiple comparisons (p-threshold=.003). Thus, within the same persons, different personality traits are differentially related to in vivo D2/3R availability in different striatal sub-regions.Entities:
Keywords: D(2/3)R; Dopamine; PET; Personality; [(11)C]-raclopride
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Year: 2016 PMID： 26944295 PMCID： PMC4805526 DOI： 10.1016/j.euroneuro.2016.02.010
Source DB: PubMed Journal: Eur Neuropsychopharmacol ISSN： 0924-977X Impact factor: 4.600