Misato Kobayashi1, Takeshi Iwase1, Kentaro Yamamoto1, Eimei Ra1, Kenta Murotani2, Shigeyuki Matsui3, Hiroko Terasaki1. 1. Department of Ophthalmology Nagoya University Graduate School of Medicine, Nagoya, Japan. 2. Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan. 3. Department of Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Showa-ku, Japan.
Abstract
PURPOSE: The purpose of this study was to evaluate foveal regeneration and the association between retinal restoration and visual acuity following reattachment surgery for rhegmatogenous retinal detachment (RRD). METHODS: Twenty-nine eyes of 29 patients with successfully reattached macula-off RRD were retrospectively analyzed. We used spectral-domain optical coherence tomography to image macular regions and measure retinal thickness and Snellen chart visual acuity (VA) to evaluate best-corrected VA (BCVA) at 1, 2, 3, 6, 9, and 12 months after vitrectomy. Best-corrected visual acuity data were converted to the logarithm of the minimum angle of resolution scale. Opposite eyes were used as controls. RESULTS: The thicknesses of the external limiting membrane (ELM)-ellipsoid zone (EZ) and EZ-retinal pigment epithelium (RPE) were significantly thinner in involved eyes than in corresponding unaffected eyes at 1 month after surgery (P < 0.001 for both), and the thickness increased over time (P < 0.001 for both). Best-corrected visual acuity significantly improved over time (P < 0.001), and the improvement correlated with EZ-RPE thickness (r = -0.45, P = 0.021). Multiple regression analysis demonstrated the presence of a foveal bulge as the independent predictor of final BCVA (P < 0.001). Eyes with a foveal bulge had significantly better BCVA and greater EZ-RPE thickness than those without throughout the follow-up period. Significant restoration of the integrity of EZ and cone interdigitation zone (CIZ) was observed over time (P < 0.001 for both) in eyes with a foveal bulge. CONCLUSIONS: The thickness of EZ-RPE and cone density increased during foveal regeneration, as demonstrated by the continuous improvements in CIZ integrity over time, leading to the formation of foveal bulge and good vision following successful reattachment of macula-off RRD.
PURPOSE: The purpose of this study was to evaluate foveal regeneration and the association between retinal restoration and visual acuity following reattachment surgery for rhegmatogenous retinal detachment (RRD). METHODS: Twenty-nine eyes of 29 patients with successfully reattached macula-off RRD were retrospectively analyzed. We used spectral-domain optical coherence tomography to image macular regions and measure retinal thickness and Snellen chart visual acuity (VA) to evaluate best-corrected VA (BCVA) at 1, 2, 3, 6, 9, and 12 months after vitrectomy. Best-corrected visual acuity data were converted to the logarithm of the minimum angle of resolution scale. Opposite eyes were used as controls. RESULTS: The thicknesses of the external limiting membrane (ELM)-ellipsoid zone (EZ) and EZ-retinal pigment epithelium (RPE) were significantly thinner in involved eyes than in corresponding unaffected eyes at 1 month after surgery (P < 0.001 for both), and the thickness increased over time (P < 0.001 for both). Best-corrected visual acuity significantly improved over time (P < 0.001), and the improvement correlated with EZ-RPE thickness (r = -0.45, P = 0.021). Multiple regression analysis demonstrated the presence of a foveal bulge as the independent predictor of final BCVA (P < 0.001). Eyes with a foveal bulge had significantly better BCVA and greater EZ-RPE thickness than those without throughout the follow-up period. Significant restoration of the integrity of EZ and cone interdigitation zone (CIZ) was observed over time (P < 0.001 for both) in eyes with a foveal bulge. CONCLUSIONS: The thickness of EZ-RPE and cone density increased during foveal regeneration, as demonstrated by the continuous improvements in CIZ integrity over time, leading to the formation of foveal bulge and good vision following successful reattachment of macula-off RRD.
Authors: Karl Thomas Boden; Kai Januschowski; Peter Szurman; Anna-Maria Seuthe; Annekatrin Rickmann; Berthold Seitz; Mohammad Alsharairi; Stephan Leers; Philip Wakili Journal: BMJ Open Ophthalmol Date: 2021-03-08
Authors: Sana Rasool; Megha Kaushik; Rishika Chaudhary; Karen Blachford; Martin Berry; Robert A H Scott; Ann Logan; Richard J Blanch Journal: Graefes Arch Clin Exp Ophthalmol Date: 2022-01-26 Impact factor: 3.535
Authors: Audrey Giocanti-Aurégan; Elige A Chbat; Christophe G H Morel; Bruno R Morin; John G Conrath; François C Devin Journal: BMC Ophthalmol Date: 2017-12-04 Impact factor: 2.209